ID   STX19_BOVIN             Reviewed;         292 AA.
AC   Q0VCI2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Syntaxin-19;
GN   Name=STX19;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in endosomal trafficking of the epidermal growth
CC       factor receptor (EGFR). {ECO:0000250|UniProtKB:Q8R1Q0}.
CC   -!- SUBUNIT: Interacts with EGFR. {ECO:0000250|UniProtKB:Q8R1Q0}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R1Q0};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1Q0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8R1Q0}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; BC120154; AAI20155.1; -; mRNA.
DR   RefSeq; NP_001069140.1; NM_001075672.2.
DR   RefSeq; XP_010799272.1; XM_010800970.1.
DR   AlphaFoldDB; Q0VCI2; -.
DR   SMR; Q0VCI2; -.
DR   STRING; 9913.ENSBTAP00000006804; -.
DR   PaxDb; Q0VCI2; -.
DR   Ensembl; ENSBTAT00000006804; ENSBTAP00000006804; ENSBTAG00000005162.
DR   GeneID; 514487; -.
DR   KEGG; bta:514487; -.
DR   CTD; 415117; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005162; -.
DR   VGNC; VGNC:35435; STX19.
DR   eggNOG; KOG0810; Eukaryota.
DR   GeneTree; ENSGT01050000244948; -.
DR   HOGENOM; CLU_042423_2_0_1; -.
DR   InParanoid; Q0VCI2; -.
DR   OMA; MLQQGKW; -.
DR   OrthoDB; 1033833at2759; -.
DR   TreeFam; TF313763; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000005162; Expressed in prostate gland and 59 other tissues.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR   GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   CDD; cd00179; SynN; 1.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR015708; STX19.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR006011; Syntaxin_N.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   PANTHER; PTHR19957:SF29; PTHR19957:SF29; 1.
DR   Pfam; PF00804; Syntaxin; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Cytoplasm; Membrane; Reference proteome;
KW   Transport.
FT   CHAIN           1..292
FT                   /note="Syntaxin-19"
FT                   /id="PRO_0000263708"
FT   DOMAIN          209..271
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          46..122
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  33890 MW;  92D073AEE388F01D CRC64;
     MKDRLPELKQ RTKETELSKD KDVPTTEAEE QGVFLQQAVI YEREPVAERH LHEIQKLQES
     INNLTDNVQK FGQQQKSLVA SMRRFSLLKK ESSIAKEIKI QAEHINRGLD DLVKEVKKSE
     DESGPSSVVT RILKFQHAAM FRHFQQTMFT YNDTIAAKQE KCRTFIFRQL EVAGKELPEE
     EVNDMLHQGK WEVFNESLLT EISITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV
     EEQGESVNSI EMIVNGTKEY VNTTKEKFGL AVKYKKRNPC KILCCWCCPC CG