STX19_HUMAN
ID STX19_HUMAN Reviewed; 294 AA.
AC Q8N4C7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Syntaxin-19;
GN Name=STX19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhang Z., Low S.H., Li X., Miura M., Kudo N., Hofmann K., Weimbs T.;
RT "Cloning, expression and characterization of a novel human SNARE protein
RT syntaxin-19 in MDCK cells.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH EGFR.
RX PubMed=16420529; DOI=10.1111/j.1600-0854.2005.00378.x;
RA Wang Y., Foo L.Y., Guo K., Gan B.Q., Zeng Q., Hong W., Tang B.L.;
RT "Syntaxin 9 is enriched in skin hair follicle epithelium and interacts with
RT the epidermal growth factor receptor.";
RL Traffic 7:216-226(2006).
CC -!- FUNCTION: Plays a role in endosomal trafficking of the epidermal growth
CC factor receptor (EGFR). {ECO:0000250|UniProtKB:Q8R1Q0}.
CC -!- SUBUNIT: Interacts with EGFR. {ECO:0000269|PubMed:16420529}.
CC -!- INTERACTION:
CC Q8N4C7; P01023: A2M; NbExp=3; IntAct=EBI-8484990, EBI-640741;
CC Q8N4C7; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-8484990, EBI-11096309;
CC Q8N4C7; P28329-3: CHAT; NbExp=3; IntAct=EBI-8484990, EBI-25837549;
CC Q8N4C7; P50570-2: DNM2; NbExp=3; IntAct=EBI-8484990, EBI-10968534;
CC Q8N4C7; P22607: FGFR3; NbExp=3; IntAct=EBI-8484990, EBI-348399;
CC Q8N4C7; P06396: GSN; NbExp=3; IntAct=EBI-8484990, EBI-351506;
CC Q8N4C7; P01112: HRAS; NbExp=3; IntAct=EBI-8484990, EBI-350145;
CC Q8N4C7; O60341: KDM1A; NbExp=2; IntAct=EBI-8484990, EBI-710124;
CC Q8N4C7; O14901: KLF11; NbExp=3; IntAct=EBI-8484990, EBI-948266;
CC Q8N4C7; Q9H115: NAPB; NbExp=3; IntAct=EBI-8484990, EBI-3921185;
CC Q8N4C7; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-8484990, EBI-2811583;
CC Q8N4C7; O43741: PRKAB2; NbExp=4; IntAct=EBI-8484990, EBI-1053424;
CC Q8N4C7; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-8484990, EBI-748391;
CC Q8N4C7; P60880-2: SNAP25; NbExp=3; IntAct=EBI-8484990, EBI-12177361;
CC Q8N4C7; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-8484990, EBI-5235340;
CC Q8N4C7; P61764: STXBP1; NbExp=9; IntAct=EBI-8484990, EBI-960169;
CC Q8N4C7; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-8484990, EBI-740595;
CC Q8N4C7; O43463: SUV39H1; NbExp=2; IntAct=EBI-8484990, EBI-349968;
CC Q8N4C7; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-8484990, EBI-6872807;
CC Q8N4C7; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-8484990, EBI-373456;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R1Q0};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1Q0}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8R1Q0}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; AF461456; AAQ04780.1; -; mRNA.
DR EMBL; BC034696; AAH34696.1; -; mRNA.
DR CCDS; CCDS33793.1; -.
DR RefSeq; NP_001001850.1; NM_001001850.2.
DR RefSeq; XP_011511144.1; XM_011512842.2.
DR AlphaFoldDB; Q8N4C7; -.
DR SMR; Q8N4C7; -.
DR BioGRID; 136105; 27.
DR IntAct; Q8N4C7; 33.
DR MINT; Q8N4C7; -.
DR STRING; 9606.ENSP00000320679; -.
DR TCDB; 8.A.91.1.8; the syntaxin (syntaxin) family.
DR iPTMnet; Q8N4C7; -.
DR PhosphoSitePlus; Q8N4C7; -.
DR SwissPalm; Q8N4C7; -.
DR BioMuta; STX19; -.
DR DMDM; 74728839; -.
DR MassIVE; Q8N4C7; -.
DR PaxDb; Q8N4C7; -.
DR PeptideAtlas; Q8N4C7; -.
DR PRIDE; Q8N4C7; -.
DR ProteomicsDB; 71916; -.
DR Antibodypedia; 32081; 125 antibodies from 19 providers.
DR DNASU; 415117; -.
DR Ensembl; ENST00000315099.3; ENSP00000320679.2; ENSG00000178750.3.
DR GeneID; 415117; -.
DR KEGG; hsa:415117; -.
DR MANE-Select; ENST00000315099.3; ENSP00000320679.2; NM_001001850.3; NP_001001850.1.
DR UCSC; uc003drh.2; human.
DR CTD; 415117; -.
DR GeneCards; STX19; -.
DR HGNC; HGNC:19300; STX19.
DR HPA; ENSG00000178750; Tissue enhanced (epididymis, intestine).
DR neXtProt; NX_Q8N4C7; -.
DR OpenTargets; ENSG00000178750; -.
DR PharmGKB; PA142670857; -.
DR VEuPathDB; HostDB:ENSG00000178750; -.
DR eggNOG; KOG0810; Eukaryota.
DR GeneTree; ENSGT01050000244948; -.
DR HOGENOM; CLU_042423_2_0_1; -.
DR InParanoid; Q8N4C7; -.
DR OMA; MLQQGKW; -.
DR OrthoDB; 1033833at2759; -.
DR PhylomeDB; Q8N4C7; -.
DR TreeFam; TF313763; -.
DR PathwayCommons; Q8N4C7; -.
DR SignaLink; Q8N4C7; -.
DR BioGRID-ORCS; 415117; 15 hits in 1067 CRISPR screens.
DR GenomeRNAi; 415117; -.
DR Pharos; Q8N4C7; Tdark.
DR PRO; PR:Q8N4C7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8N4C7; protein.
DR Bgee; ENSG00000178750; Expressed in mucosa of transverse colon and 111 other tissues.
DR Genevisible; Q8N4C7; HS.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR CDD; cd00179; SynN; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR015708; STX19.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR PANTHER; PTHR19957:SF29; PTHR19957:SF29; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Cytoplasm; Membrane; Reference proteome;
KW Transport.
FT CHAIN 1..294
FT /note="Syntaxin-19"
FT /id="PRO_0000263709"
FT DOMAIN 209..271
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
SQ SEQUENCE 294 AA; 34324 MW; 1A7FE896916DCE57 CRC64;
MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH LHEIQKLQES
INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI QAEYINRSLN DLVKEVKKSE
VENGPSSVVT RILKSQHAAM FRHFQQIMFI YNDTIAAKQE KCKTFILRQL EVAGKEMSEE
DVNDMLHQGK WEVFNESLLT EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV
EEQGESINNI EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK
