STX19_MOUSE
ID STX19_MOUSE Reviewed; 292 AA.
AC Q8R1Q0; Q9CTR6; Q9CV39;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Syntaxin-19 {ECO:0000312|MGI:MGI:1915409};
DE AltName: Full=Syntaxin-9 {ECO:0000303|PubMed:16420529};
GN Name=Stx19 {ECO:0000312|MGI:MGI:1915409};
GN Synonyms=Syn9 {ECO:0000303|PubMed:16420529};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, INTERACTION WITH EGFR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=16420529; DOI=10.1111/j.1600-0854.2005.00378.x;
RA Wang Y., Foo L.Y., Guo K., Gan B.Q., Zeng Q., Hong W., Tang B.L.;
RT "Syntaxin 9 is enriched in skin hair follicle epithelium and interacts with
RT the epidermal growth factor receptor.";
RL Traffic 7:216-226(2006).
CC -!- FUNCTION: Plays a role in endosomal trafficking of the epidermal growth
CC factor receptor (EGFR). {ECO:0000269|PubMed:16420529}.
CC -!- SUBUNIT: Interacts with EGFR. {ECO:0000269|PubMed:16420529}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16420529};
CC Peripheral membrane protein {ECO:0000305}. Cytoplasm
CC {ECO:0000269|PubMed:16420529}.
CC -!- TISSUE SPECIFICITY: Expressed in stomach, lung and skin (at protein
CC level). In stomach, strongly expressed in the mucosa of the fundus, in
CC epithelial cells of gastric pits, and in gastric glands (at protein
CC level). In skin, expressed in the epidermis, dermis, and epithelial
CC layer of the hair bulb (at protein level).
CC {ECO:0000269|PubMed:16420529}.
CC -!- DEVELOPMENTAL STAGE: Detected in stomach and skin from embryonic stage
CC 16 (16 dpc) onwards. {ECO:0000269|PubMed:16420529}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26492.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK009770; BAB26492.1; ALT_FRAME; mRNA.
DR EMBL; AK020701; BAB32182.3; -; mRNA.
DR EMBL; BC023414; AAH23414.1; -; mRNA.
DR CCDS; CCDS28262.1; -.
DR RefSeq; NP_080864.1; NM_026588.1.
DR AlphaFoldDB; Q8R1Q0; -.
DR SMR; Q8R1Q0; -.
DR BioGRID; 212688; 2.
DR STRING; 10090.ENSMUSP00000055901; -.
DR PhosphoSitePlus; Q8R1Q0; -.
DR PaxDb; Q8R1Q0; -.
DR PRIDE; Q8R1Q0; -.
DR ProteomicsDB; 257471; -.
DR Antibodypedia; 32081; 125 antibodies from 19 providers.
DR DNASU; 68159; -.
DR Ensembl; ENSMUST00000055557; ENSMUSP00000055901; ENSMUSG00000047854.
DR GeneID; 68159; -.
DR KEGG; mmu:68159; -.
DR UCSC; uc007zpv.1; mouse.
DR CTD; 415117; -.
DR MGI; MGI:1915409; Stx19.
DR VEuPathDB; HostDB:ENSMUSG00000047854; -.
DR eggNOG; KOG0810; Eukaryota.
DR GeneTree; ENSGT01050000244948; -.
DR HOGENOM; CLU_042423_2_0_1; -.
DR InParanoid; Q8R1Q0; -.
DR OMA; MLQQGKW; -.
DR OrthoDB; 1033833at2759; -.
DR PhylomeDB; Q8R1Q0; -.
DR TreeFam; TF313763; -.
DR BioGRID-ORCS; 68159; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8R1Q0; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8R1Q0; protein.
DR Bgee; ENSMUSG00000047854; Expressed in epithelium of stomach and 39 other tissues.
DR Genevisible; Q8R1Q0; MM.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR CDD; cd00179; SynN; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR015708; STX19.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR PANTHER; PTHR19957:SF29; PTHR19957:SF29; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Cytoplasm; Membrane; Reference proteome;
KW Transport.
FT CHAIN 1..292
FT /note="Syntaxin-19"
FT /id="PRO_0000263710"
FT DOMAIN 207..269
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT CONFLICT 270
FT /note="V -> A (in Ref. 1; BAB32182)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 33867 MW; 468A530150D1D021 CRC64;
MKDRLQELKQ KTKEIELSRD GQVFVEEEQG VLVQQAVIYE REPVAERHLH EIQKLQENIN
SFVDDVQRFG QQQKSLVASM RRFSLLKRDS TIAKEIKIQA EHINRALGDV VKEVKKSEVE
NGPSSVVTRI LKSQYAAMFR RFQQTMFLYN DTIALKQEKC KTFIVRQLEV AGKEVSEEEV
NDMLHHGKWE VFNESLLTET SITKAQLSEI EQRHKELVNL ENQVKDLRDL FIQISLLVEE
QGESINSIEV MVNSTKDYVN NTKEKFGLAV KYKKRNPCRA LCCCCCPRCG SK
