ID   STX2_CAEEL              Reviewed;         299 AA.
AC   Q20574;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 4.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Putative syntaxin-2;
GN   Name=syx-2; Synonyms=syn-2; ORFNames=F48F7.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Potentially involved in docking of synaptic vesicles at
CC       presynaptic active zones. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z69661; CAA93492.4; -; Genomic_DNA.
DR   PIR; E89697; E89697.
DR   PIR; T22390; T22390.
DR   RefSeq; NP_510323.3; NM_077922.4.
DR   AlphaFoldDB; Q20574; -.
DR   SMR; Q20574; -.
DR   STRING; 6239.F48F7.2.2; -.
DR   iPTMnet; Q20574; -.
DR   EPD; Q20574; -.
DR   PaxDb; Q20574; -.
DR   PeptideAtlas; Q20574; -.
DR   EnsemblMetazoa; F48F7.2.1; F48F7.2.1; WBGene00006372.
DR   GeneID; 181505; -.
DR   KEGG; cel:CELE_F48F7.2; -.
DR   UCSC; F48F7.2.1; c. elegans.
DR   CTD; 181505; -.
DR   WormBase; F48F7.2; CE37520; WBGene00006372; syx-2.
DR   eggNOG; KOG0810; Eukaryota.
DR   GeneTree; ENSGT01050000244948; -.
DR   HOGENOM; CLU_931369_0_0_1; -.
DR   InParanoid; Q20574; -.
DR   OMA; HADYRSR; -.
DR   OrthoDB; 1146282at2759; -.
DR   PhylomeDB; Q20574; -.
DR   PRO; PR:Q20574; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006372; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0007614; P:short-term memory; IGI:WormBase.
DR   GO; GO:0016081; P:synaptic vesicle docking; ISS:UniProtKB.
DR   GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR   GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   CDD; cd00179; SynN; 1.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR006011; Syntaxin_N.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF00804; Syntaxin; 1.
DR   SMART; SM00503; SynN; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Neurotransmitter transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..299
FT                   /note="Putative syntaxin-2"
FT                   /id="PRO_0000210240"
FT   TOPO_DOM        1..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..299
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          193..255
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   COILED          112..146
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  34506 MW;  83B18CD4872E783C CRC64;
     MRDRLNEFQS RVTDRFDEVE LSPARPPSAA EYVDRRFEEV RNAIASVRGE IEKLRRDQQH
     VLALTIADPR DKNILENQIG TIRRRTGDLR KLVRQAEDDF LEFTKQVQSV TEKRMRQNQL
     ELLKDNLNKL INLFNETHQD YKSRVSVRVR RQLQTVGQDL TDEDINRIME NSGSEQLFFR
     EVNPLSVSGQ AAYEDVKKRH GEIKDLENNI AMLEEIFLDL QHLTEAQDEM VTNIDNNVEN
     GLEQVKQGSA NVKTAVEYKK SAMRKKICVA AILITILLIL IIVAIILAVV LSRGNNNNK