STX2_MOUSE
ID STX2_MOUSE Reviewed; 289 AA.
AC Q00262;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 25-MAY-2022, entry version 146.
DE RecName: Full=Syntaxin-2;
DE AltName: Full=Epimorphin;
GN Name=Stx2; Synonyms=Epim;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1581962; DOI=10.1016/0092-8674(92)90448-l;
RA Hirai Y., Takebe K., Takashina M., Kobayashi S., Takeichi M.;
RT "Epimorphin: a mesenchymal protein essential for epithelial
RT morphogenesis.";
RL Cell 69:471-481(1992).
RN [2]
RP FUNCTION.
RX PubMed=7957204; DOI=10.1111/j.1432-1033.1994.1133b.x;
RA Hirai Y.;
RT "Sodium-dodecyl-sulfate-resistant complex formation of epimorphin monomers
RT and interaction of the 150-kDa complex with the cell surface.";
RL Eur. J. Biochem. 225:1133-1139(1994).
RN [3]
RP FUNCTION, AND INTERACTION WITH SYT6 AND SYT8.
RX PubMed=15774481; DOI=10.1074/jbc.m412920200;
RA Hutt D.M., Baltz J.M., Ngsee J.K.;
RT "Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm
RT acrosome reaction.";
RL J. Biol. Chem. 280:20197-20203(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential for epithelial morphogenesis. May mediate Ca(2+)-
CC regulation of exocytosis acrosomal reaction in sperm.
CC {ECO:0000269|PubMed:15774481, ECO:0000269|PubMed:7957204}.
CC -!- SUBUNIT: Interacts with SYT6 and SYT8; the interaction is Ca(2+)-
CC dependent. {ECO:0000269|PubMed:15774481}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; D10475; BAA01278.1; -; mRNA.
DR CCDS; CCDS19692.1; -.
DR PIR; A38216; S51193.
DR AlphaFoldDB; Q00262; -.
DR SMR; Q00262; -.
DR STRING; 10090.ENSMUSP00000031378; -.
DR iPTMnet; Q00262; -.
DR PhosphoSitePlus; Q00262; -.
DR EPD; Q00262; -.
DR jPOST; Q00262; -.
DR MaxQB; Q00262; -.
DR PaxDb; Q00262; -.
DR PeptideAtlas; Q00262; -.
DR PRIDE; Q00262; -.
DR ProteomicsDB; 254608; -.
DR MGI; MGI:108059; Stx2.
DR eggNOG; KOG0810; Eukaryota.
DR InParanoid; Q00262; -.
DR PhylomeDB; Q00262; -.
DR ChiTaRS; Stx2; mouse.
DR PRO; PR:Q00262; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q00262; protein.
DR GO; GO:0016323; C:basolateral plasma membrane; ISO:MGI.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005911; C:cell-cell junction; IDA:MGI.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0030027; C:lamellipodium; ISO:MGI.
DR GO; GO:0045121; C:membrane raft; IDA:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; ISO:MGI.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR GO; GO:0048306; F:calcium-dependent protein binding; IPI:HGNC-UCL.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; ISO:MGI.
DR GO; GO:0005198; F:structural molecule activity; ISO:MGI.
DR GO; GO:0007340; P:acrosome reaction; IDA:HGNC-UCL.
DR GO; GO:0030154; P:cell differentiation; IDA:MGI.
DR GO; GO:0034599; P:cellular response to oxidative stress; ISO:MGI.
DR GO; GO:1903575; P:cornified envelope assembly; ISO:MGI.
DR GO; GO:0048546; P:digestive tract morphogenesis; ISO:MGI.
DR GO; GO:0007566; P:embryo implantation; IC:MGI.
DR GO; GO:0030855; P:epithelial cell differentiation; ISO:MGI.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0030033; P:microvillus assembly; ISO:MGI.
DR GO; GO:0061952; P:midbody abscission; ISO:MGI.
DR GO; GO:0000281; P:mitotic cytokinesis; ISO:MGI.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR CDD; cd00179; SynN; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR028671; STX2.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR PANTHER; PTHR19957:SF36; PTHR19957:SF36; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..289
FT /note="Syntaxin-2"
FT /id="PRO_0000210197"
FT TOPO_DOM 1..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..289
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT DOMAIN 192..254
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT COILED 68..101
FT /evidence="ECO:0000255"
SQ SEQUENCE 289 AA; 33178 MW; 9D82330D0F5CA2F4 CRC64;
MRDRLPDLTA CRTNDDGDTA VVIVEKDHFM DGFFHQVEEI RSSIARIAQH VEDVKKNHSI
ILSAPNPEGK IKEELEDLDK EIKKTANRIR GKLKSIEQSC DQDENGNRTS VDLRIRRTQH
SVLSRKFVDV MTEYNEAQIL FRERSKGRIQ RQLEITGRTT TDDELEEMLE SGKPSIFISD
IISDSQITRQ ALNEIESRHK DIMKLETSIR ELHEMFMDMA MFVETQGEMV NNIERNVVNS
VDYVEHAKEE TKKAIKYQSK ARRKKWIIAA VAVAVIAVLA LIIGLSVGK
