ID   STX4_CAEEL              Reviewed;         287 AA.
AC   P91409;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Putative syntaxin-4;
GN   Name=syx-4; Synonyms=syn-4; ORFNames=T01B11.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Potentially involved in docking of synaptic vesicles at
CC       presynaptic active zones. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P91409; O62305: unc-43; NbExp=3; IntAct=EBI-326499, EBI-313095;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; FO080698; CCD65924.1; -; Genomic_DNA.
DR   PIR; T25849; T25849.
DR   RefSeq; NP_501439.2; NM_069038.3.
DR   AlphaFoldDB; P91409; -.
DR   SMR; P91409; -.
DR   BioGRID; 42759; 3.
DR   DIP; DIP-26921N; -.
DR   IntAct; P91409; 2.
DR   STRING; 6239.T01B11.3; -.
DR   EPD; P91409; -.
DR   PaxDb; P91409; -.
DR   PeptideAtlas; P91409; -.
DR   EnsemblMetazoa; T01B11.3.1; T01B11.3.1; WBGene00006374.
DR   GeneID; 177647; -.
DR   KEGG; cel:CELE_T01B11.3; -.
DR   UCSC; T01B11.3; c. elegans.
DR   CTD; 177647; -.
DR   WormBase; T01B11.3; CE43759; WBGene00006374; syx-4.
DR   eggNOG; KOG0810; Eukaryota.
DR   GeneTree; ENSGT01050000244948; -.
DR   HOGENOM; CLU_042423_4_0_1; -.
DR   InParanoid; P91409; -.
DR   OrthoDB; 1383930at2759; -.
DR   PhylomeDB; P91409; -.
DR   Reactome; R-CEL-449836; Other interleukin signaling.
DR   PRO; PR:P91409; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006374; Expressed in germ line (C elegans) and 3 other tissues.
DR   GO; GO:0032154; C:cleavage furrow; IDA:WormBase.
DR   GO; GO:0060473; C:cortical granule; IDA:WormBase.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:WormBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0060471; P:cortical granule exocytosis; IMP:WormBase.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0032467; P:positive regulation of cytokinesis; IMP:WormBase.
DR   GO; GO:0017157; P:regulation of exocytosis; IMP:UniProtKB.
DR   GO; GO:0016081; P:synaptic vesicle docking; ISS:UniProtKB.
DR   GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR   GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR006011; Syntaxin_N.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF00804; Syntaxin; 1.
DR   SMART; SM00503; SynN; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Membrane; Neurotransmitter transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Putative syntaxin-4"
FT                   /id="PRO_0000210242"
FT   TOPO_DOM        1..262
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..287
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          184..246
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   COILED          65..97
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  32316 MW;  04F8FE96409F389C CRC64;
     MHQISGINAA SPEKNNSKLA DVSLQQFLAN VDEIRHVLTT LSADRHAIYM EQVESLAAGC
     SDTAKCRKLN DHVDKFIAQA RGIRRRLADA SEELVQYPES RVGSGRARHE QIQMLIVSLE
     GIMSQFADDQ ASYKAEAAKK IAAYLRKQNI EVTDSEIDGA IENGSLFQLT RNINLGVAQK
     KALFDDMKNR ATDIMILEKQ IREVEELFVD MQLLVQSQGE TVDRIETSVI RAEEYAEQAQ
     QNVRQAVVLR RKNRKWKIVT CIALIVLLLV VVYLLSHFLG AIIPGWK