STX5_BOVIN
ID STX5_BOVIN Reviewed; 355 AA.
AC Q08DB5;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Syntaxin-5;
GN Name=STX5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates endoplasmic reticulum to Golgi transport. Together
CC with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and
CC fusion at the cis-Golgi membrane to maintain the stacked and inter-
CC connected structure of the Golgi apparatus.
CC {ECO:0000250|UniProtKB:Q08851}.
CC -!- SUBUNIT: Part of a ternary complex containing STX5A, NSFL1C and VCP (By
CC similarity). Part of a unique SNARE complex composed of the Golgi
CC SNAREs GOSR1, GOSR2 and YKT6. This complex also includes VTI1A (By
CC similarity). Interacts with COG4 (By similarity). Interacts with
CC GM130/GOLGA2 (By similarity). Interacts (via IxM motif) with SEC24C and
CC SEC24D; mediates STX5 packaging into COPII-coated vesicles (By
CC similarity). Interacts with VLDLR; this interaction mediates VLDLR
CC translocation from the endoplasmic reticulum to the plasma membrane (By
CC similarity). {ECO:0000250|UniProtKB:Q08851,
CC ECO:0000250|UniProtKB:Q13190, ECO:0000250|UniProtKB:Q8K1E0}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000250|UniProtKB:Q08851}; Single-pass type
CC IV membrane protein {ECO:0000255}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q08851}. Note=Localizes throughout the Golgi
CC apparatus, but most abundant in the cis-most cisternae.
CC {ECO:0000250|UniProtKB:Q08851}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; BC123843; AAI23844.1; -; mRNA.
DR RefSeq; NP_001068912.1; NM_001075444.1.
DR RefSeq; XP_005226961.1; XM_005226904.3.
DR RefSeq; XP_005226962.1; XM_005226905.3.
DR AlphaFoldDB; Q08DB5; -.
DR SMR; Q08DB5; -.
DR STRING; 9913.ENSBTAP00000043848; -.
DR PaxDb; Q08DB5; -.
DR Ensembl; ENSBTAT00000046561; ENSBTAP00000043848; ENSBTAG00000009490.
DR GeneID; 510312; -.
DR KEGG; bta:510312; -.
DR CTD; 6811; -.
DR VEuPathDB; HostDB:ENSBTAG00000009490; -.
DR VGNC; VGNC:35441; STX5.
DR eggNOG; KOG0812; Eukaryota.
DR GeneTree; ENSGT01000000214440; -.
DR HOGENOM; CLU_044998_0_1_1; -.
DR InParanoid; Q08DB5; -.
DR OMA; RGITGTM; -.
DR OrthoDB; 1297427at2759; -.
DR TreeFam; TF315068; -.
DR Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR Reactome; R-BTA-5694530; Cargo concentration in the ER.
DR Reactome; R-BTA-6811438; Intra-Golgi traffic.
DR Reactome; R-BTA-8980692; RHOA GTPase cycle.
DR Reactome; R-BTA-9013408; RHOG GTPase cycle.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000009490; Expressed in saliva-secreting gland and 105 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0034498; P:early endosome to Golgi transport; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0090166; P:Golgi disassembly; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:1903358; P:regulation of Golgi organization; IEA:Ensembl.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR021538; Syntaxin-5_N.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF11416; Syntaxin-5_N; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..355
FT /note="Syntaxin-5"
FT /id="PRO_0000284072"
FT TOPO_DOM 1..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 355
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 263..325
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT REGION 28..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 287..318
FT /evidence="ECO:0000255"
FT MOTIF 245..247
FT /note="IxM motif; signal for cargo packaging into COPII-
FT coated vesicles"
FT /evidence="ECO:0000250|UniProtKB:Q13190"
SQ SEQUENCE 355 AA; 39546 MW; 1E6E1A2CAF912B89 CRC64;
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVALVPP PPDTMSCRDR
TQEFLSACKS LQSRQNGIQA NKPALRAVRQ RSEFTLMAKR IGKDLSNTFA KLEKLTILAK
RKSLFDDKAV EIEELTYIIK QDINSLNKQI AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ
SKLASMSNDF KSVLEVRTEN LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESRAS
GDVAIDMMDS RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF VVFLA
