ID   STX5_CAEEL              Reviewed;         413 AA.
AC   Q20797;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Putative syntaxin-5;
GN   Name=syx-5; Synonyms=syn-3; ORFNames=F55A11.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Potentially involved in docking of synaptic vesicles at
CC       presynaptic active zones. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; Z72511; CAA96656.1; -; Genomic_DNA.
DR   PIR; T22686; T22686.
DR   RefSeq; NP_505968.1; NM_073567.6.
DR   AlphaFoldDB; Q20797; -.
DR   SMR; Q20797; -.
DR   BioGRID; 44636; 5.
DR   IntAct; Q20797; 4.
DR   STRING; 6239.F55A11.2; -.
DR   iPTMnet; Q20797; -.
DR   EPD; Q20797; -.
DR   PaxDb; Q20797; -.
DR   PeptideAtlas; Q20797; -.
DR   PRIDE; Q20797; -.
DR   EnsemblMetazoa; F55A11.2.1; F55A11.2.1; WBGene00006373.
DR   GeneID; 179611; -.
DR   KEGG; cel:CELE_F55A11.2; -.
DR   UCSC; F55A11.2; c. elegans.
DR   CTD; 179611; -.
DR   WormBase; F55A11.2; CE05944; WBGene00006373; syx-5.
DR   eggNOG; KOG0812; Eukaryota.
DR   GeneTree; ENSGT01000000214440; -.
DR   HOGENOM; CLU_044998_1_1_1; -.
DR   InParanoid; Q20797; -.
DR   OMA; RGITGTM; -.
DR   OrthoDB; 1297427at2759; -.
DR   PhylomeDB; Q20797; -.
DR   Reactome; R-CEL-204005; COPII-mediated vesicle transport.
DR   Reactome; R-CEL-5694530; Cargo concentration in the ER.
DR   Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR   Reactome; R-CEL-9013106; RHOC GTPase cycle.
DR   Reactome; R-CEL-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   PRO; PR:Q20797; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00006373; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016081; P:synaptic vesicle docking; ISS:UniProtKB.
DR   GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR021538; Syntaxin-5_N.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF11416; Syntaxin-5_N; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Neurotransmitter transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..413
FT                   /note="Putative syntaxin-5"
FT                   /id="PRO_0000210241"
FT   TOPO_DOM        1..391
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        413
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          321..383
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   REGION          257..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  45853 MW;  41DB9C1634BC493A CRC64;
     MSDFHNIRSR RRIPEASSYS TVDFDYDPDQ KNHTSAVAPT SFAYSSLTTV FNASASQLWN
     SAQEALVSSY DTAEGTESID ADRSKVVETL ESLSIFGNPL DHIIITMPSR DRTSEFRATA
     KSYEMKAAAN GIRPQPKHEM LSESVQFNQL AKRIGKELSQ TCAKMEKLAE YAKKKSCYEE
     RSQIDHLSSI VKSDITGLNK QIGQLQEFSK RRAGNMKNQN SGHIQLVVVG LQSKLANVGK
     DYQSVLEIST ETMKAEKNRR DKFSSGAAVP MGLPSSSSGA NVRSKLLQDD EQHGSSSIAL
     DMGALSNMQS QQTMQQRDSS LEYAQARSNT MATIEGSISE LGQIFSQLAS LVSEQGEMIT
     RIDSNVEDTA LNIDMAHSEL VRYLQNISKN RWLMIQVFGV LMVFFVVFVL FLT