ID   STX6_CHICK              Reviewed;         254 AA.
AC   Q5ZL19;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Syntaxin-6;
GN   Name=STX6; ORFNames=RCJMB04_8d16;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in intracellular vesicle trafficking. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:O43752}; Single-pass type IV membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; AJ719915; CAG31574.1; -; mRNA.
DR   RefSeq; NP_001006531.1; NM_001006531.1.
DR   AlphaFoldDB; Q5ZL19; -.
DR   SMR; Q5ZL19; -.
DR   STRING; 9031.ENSGALP00000006160; -.
DR   PaxDb; Q5ZL19; -.
DR   PRIDE; Q5ZL19; -.
DR   Ensembl; ENSGALT00000006170; ENSGALP00000006160; ENSGALG00000003880.
DR   GeneID; 424413; -.
DR   KEGG; gga:424413; -.
DR   CTD; 8677; -.
DR   VEuPathDB; HostDB:geneid_424413; -.
DR   eggNOG; KOG3202; Eukaryota.
DR   GeneTree; ENSGT00940000157639; -.
DR   HOGENOM; CLU_061883_1_0_1; -.
DR   InParanoid; Q5ZL19; -.
DR   OMA; EHDPYRF; -.
DR   OrthoDB; 1563292at2759; -.
DR   PhylomeDB; Q5ZL19; -.
DR   Reactome; R-GGA-6811438; Intra-Golgi traffic.
DR   Reactome; R-GGA-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   PRO; PR:Q5ZL19; -.
DR   Proteomes; UP000000539; Chromosome 8.
DR   Bgee; ENSGALG00000003880; Expressed in spleen and 13 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; ISS:AgBase.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0030285; C:integral component of synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:AgBase.
DR   GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IEA:Ensembl.
DR   GO; GO:0032456; P:endocytic recycling; IEA:Ensembl.
DR   GO; GO:0007032; P:endosome organization; ISS:AgBase.
DR   GO; GO:0090161; P:Golgi ribbon formation; IEA:Ensembl.
DR   GO; GO:0048193; P:Golgi vesicle transport; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; ISS:AgBase.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR015260; Syntaxin-6_N.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF09177; Syntaxin-6_N; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..254
FT                   /note="Syntaxin-6"
FT                   /id="PRO_0000210212"
FT   TOPO_DOM        1..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          162..224
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   REGION          103..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          46..72
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        103..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   254 AA;  29155 MW;  704D97BCE83317AD CRC64;
     MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSIATR EEIDWTTNEL RNNLRSIEWD
     LEDLDETISI VEANPRKFNL DATELGIRKS FITSTRQVVR EMKDQMSNSS MQALAERKNR
     QALLGESSSQ SWSSGPDKYS RLDRELQLAN SHFIEEQQAQ QQLIVEQQDE QLELVSGSIG
     VLKNMSQRIG GELEEQAVML DDFSHELDST HSRLDNVMKK LAKVSHMTSD RRQWCAIIVL
     FVILLVVLVL FLVL