STX8A_DICDI
ID STX8A_DICDI Reviewed; 152 AA.
AC Q553P5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Syntaxin-8A;
GN Name=syn8A {ECO:0000312|EMBL:EAL69780.1};
GN Synonyms=syn8 {ECO:0000312|dictyBase:DDB_G0275429}; ORFNames=DDB_G0275429;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000312|EMBL:EAL69780.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 16-28, FUNCTION, IDENTIFICATION IN SNARE COMPLEX, AND
RP SUBCELLULAR LOCATION.
RX PubMed=12175335; DOI=10.1042/bj20020845;
RA Bogdanovic A., Bennett N., Kieffer S., Louwagie M., Morio T., Garin J.,
RA Satre M., Bruckert F.;
RT "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane
RT protein 7) form an active SNARE complex for early macropinocytic
RT compartment fusion in Dictyostelium discoideum.";
RL Biochem. J. 368:29-39(2002).
CC -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC to their target membrane during transport of proteins from the early
CC endosome to the lysosome. Required for fusion of late endosomes with
CC lysosomes and homotypic lysosomal fusion.
CC {ECO:0000269|PubMed:12175335}.
CC -!- SUBUNIT: Component of the SNARE complex composed of syn7A, syn8A,
CC vamp7A and vti1A. {ECO:0000269|PubMed:12175335}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:12175335};
CC Single-pass membrane protein {ECO:0000255,
CC ECO:0000269|PubMed:12175335}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000255}.
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DR EMBL; AAFI02000013; EAL69780.1; -; Genomic_DNA.
DR RefSeq; XP_643701.1; XM_638609.1.
DR AlphaFoldDB; Q553P5; -.
DR SMR; Q553P5; -.
DR IntAct; Q553P5; 1.
DR STRING; 44689.DDB0231533; -.
DR PaxDb; Q553P5; -.
DR EnsemblProtists; EAL69780; EAL69780; DDB_G0275429.
DR GeneID; 8619970; -.
DR KEGG; ddi:DDB_G0275429; -.
DR dictyBase; DDB_G0275429; syn8A.
DR eggNOG; KOG3202; Eukaryota.
DR HOGENOM; CLU_1725718_0_0_1; -.
DR InParanoid; Q553P5; -.
DR OMA; GHWICIC; -.
DR PhylomeDB; Q553P5; -.
DR PRO; PR:Q553P5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005768; C:endosome; IDA:dictyBase.
DR GO; GO:0010008; C:endosome membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031201; C:SNARE complex; IDA:dictyBase.
DR GO; GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB.
DR GO; GO:0006906; P:vesicle fusion; IDA:UniProtKB.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR Pfam; PF05739; SNARE; 1.
DR SMART; SM00397; t_SNARE; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Endosome; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..152
FT /note="Syntaxin-8A"
FT /id="PRO_0000319998"
FT TOPO_DOM 1..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9UNK0, ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Anchor for type IV membrane protein"
FT DOMAIN 60..122
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 152 AA; 17204 MW; 8BF459D2878BF6B4 CRC64;
MNNNNNFNSN FNSNRISSTQ PYLSDDARNA LFEGKDRKWG NNNNNNYDTL SNQDVFEKQK
RDMEEQDKML DALSGSISRV KDTAITINKT AQEQTDMLDE LDVHVDSTSA RMRNTTKNLI
TLTQQSKTTG YCSAICFLLL VLLVIIILAS VL
