ID   STX8_BOVIN              Reviewed;         236 AA.
AC   Q3T075;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Syntaxin-8;
GN   Name=STX8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Vesicle trafficking protein that functions in the early
CC       secretory pathway, possibly by mediating retrograde transport from cis-
CC       Golgi membranes to the ER. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a SNARE complex with STX7, VTI1B and VAMP8 which
CC       functions in the homotypic fusion of late endosomes. Part of the SNARE
CC       core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By
CC       similarity). Interacts with HECTD3 (By similarity). Interacts with TPC1
CC       (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88983}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV
CC       membrane protein {ECO:0000250}. Note=Preferentially associated with the
CC       early endosome. To a lesser extent, also present in late endosome, the
CC       plasma membrane and coated pits (By similarity). {ECO:0000250}.
CC   -!- PTM: Ubiquitinated by HECTD3. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; BC102537; AAI02538.1; -; mRNA.
DR   RefSeq; NP_001071505.1; NM_001078037.2.
DR   AlphaFoldDB; Q3T075; -.
DR   SMR; Q3T075; -.
DR   STRING; 9913.ENSBTAP00000042059; -.
DR   PaxDb; Q3T075; -.
DR   PRIDE; Q3T075; -.
DR   Ensembl; ENSBTAT00000044575; ENSBTAP00000042059; ENSBTAG00000017815.
DR   GeneID; 613567; -.
DR   KEGG; bta:613567; -.
DR   CTD; 9482; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017815; -.
DR   VGNC; VGNC:35444; STX8.
DR   eggNOG; KOG3202; Eukaryota.
DR   GeneTree; ENSGT00390000007779; -.
DR   HOGENOM; CLU_099972_1_0_1; -.
DR   InParanoid; Q3T075; -.
DR   OMA; CGYWIVI; -.
DR   OrthoDB; 1455798at2759; -.
DR   TreeFam; TF323262; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000017815; Expressed in oocyte and 107 other tissues.
DR   ExpressionAtlas; Q3T075; baseline and differential.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   CDD; cd15852; SNARE_Syntaxin8; 1.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR041875; Syntaxin-8_SNARE.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Ubl conjugation.
FT   CHAIN           1..236
FT                   /note="Syntaxin-8"
FT                   /id="PRO_0000283810"
FT   TOPO_DOM        1..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..232
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..236
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          145..207
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   COILED          42..65
FT                   /evidence="ECO:0000255"
FT   MOD_RES         160
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O88983"
SQ   SEQUENCE   236 AA;  26760 MW;  5780230741D89500 CRC64;
     MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERNGENTTKL TVTIRALLQK LKEKIALLKD
     LLLRAVATHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMTGGAKRGA
     PNPWLLEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN
     EIIDDLANLV ENTDEKLRTE TRRVNLVDRK STSCGMIMVI LLLLVAIVVV AVWPTK