ID   STXA_ANEVI              Reviewed;          61 AA.
AC   C3TS07;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Delta-actitoxin-Avd2c {ECO:0000303|PubMed:22683676};
DE            Short=Delta-AITX-Avd2c {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Av10 {ECO:0000303|PubMed:19609479};
DE   AltName: Full=Neurotoxin 10 {ECO:0000312|EMBL:ACL12305.1};
DE   Flags: Precursor;
OS   Anemonia viridis (Snakelocks anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anemonia.
OX   NCBI_TaxID=51769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   TISSUE=Ovary;
RX   PubMed=19609479; DOI=10.1007/s00239-009-9258-x;
RA   Moran Y., Weinberger H., Lazarus N., Gur M., Kahn R., Gordon D.,
RA   Gurevitz M.;
RT   "Fusion and retrotransposition events in the evolution of the sea anemone
RT   Anemonia viridis neurotoxin genes.";
RL   J. Mol. Evol. 69:115-124(2009).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Sodium channel inhibitor. 5 uM completely inhibits voltage-
CC       gated sodium channel (Nav) inactivation. {ECO:0000269|PubMed:19609479}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sea anemone short toxin (type III) family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Opinions are divided on whether Anemonia viridis (Forsskal,
CC       1775) and Anemonia sulcata (Pennant, 1777) are separate species.
CC       {ECO:0000305}.
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DR   EMBL; EU919730; ACL12305.1; -; Genomic_DNA.
DR   AlphaFoldDB; C3TS07; -.
DR   SMR; C3TS07; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012509; Neurotoxin_3_Anemonia.
DR   InterPro; IPR036247; Neurotoxin_3_sf.
DR   Pfam; PF08098; ATX_III; 1.
DR   SUPFAM; SSF57419; SSF57419; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Nematocyst; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..31
FT                   /evidence="ECO:0000250|UniProtKB:P01535"
FT                   /id="PRO_0000433699"
FT   PEPTIDE         34..61
FT                   /note="Delta-actitoxin-Avd2c"
FT                   /id="PRO_0000433700"
FT   DISULFID        36..51
FT                   /evidence="ECO:0000250|UniProtKB:P01535"
FT   DISULFID        37..45
FT                   /evidence="ECO:0000250|UniProtKB:P01535"
FT   DISULFID        39..56
FT                   /evidence="ECO:0000250|UniProtKB:P01535"
SQ   SEQUENCE   61 AA;  6626 MW;  9DC29BB9BE70492F CRC64;
     MMNRLLVFLM LGAFMLVVSA NDAYGGDESL GKRKSCCPCW LGGNCFWGQN CYPQGCSGPK
     V