ID   STXB1_BOVIN             Reviewed;         594 AA.
AC   P61763; Q28208; Q62759; Q64320; Q96TG8;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Syntaxin-binding protein 1;
DE   AltName: Full=N-Sec1;
DE   AltName: Full=Protein unc-18 homolog 1;
DE            Short=Unc18-1;
DE   AltName: Full=Protein unc-18 homolog A;
DE            Short=Unc-18A;
DE   AltName: Full=p67;
GN   Name=STXBP1; Synonyms=UNC18A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=8247129; DOI=10.1038/366347a0;
RA   Hata Y., Slaughter C.A., Suedhof T.C.;
RT   "Synaptic vesicle fusion complex contains unc-18 homologue bound to
RT   syntaxin.";
RL   Nature 366:347-351(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Adrenal medulla;
RA   Wang G.-T., Gillis K.D.;
RT   "Bovine chromaffin cell munc18-1 cDNA deduced amino acid sequence is
RT   identical to that of rat munc18-1.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INTERACTION WITH CABP5, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=22039235; DOI=10.1167/iovs.11-8246;
RA   Sokal I., Haeseleer F.;
RT   "Insight into the role of Ca2+-binding protein 5 in vesicle exocytosis.";
RL   Invest. Ophthalmol. Vis. Sci. 52:9131-9141(2011).
CC   -!- FUNCTION: Participates in the regulation of synaptic vesicle docking
CC       and fusion through interaction with GTP-binding proteins (By
CC       similarity). Essential for neurotransmission and binds syntaxin, a
CC       component of the synaptic vesicle fusion machinery probably in a 1:1
CC       ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May
CC       play a role in determining the specificity of intracellular fusion
CC       reactions (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P61765}.
CC   -!- SUBUNIT: Interacts with SYTL4 (By similarity). Interacts with STX1A (By
CC       similarity). Interacts with alpha-synuclein/SNCA; this interaction
CC       controls SNCA self-replicating aggregation (By similarity). Interacts
CC       with RAB3A; this interaction promotes RAB3A dissociation from the
CC       vesicle membrane (By similarity). Interacts with CABP5
CC       (PubMed:22039235). {ECO:0000250|UniProtKB:P61764,
CC       ECO:0000250|UniProtKB:P61765, ECO:0000269|PubMed:22039235}.
CC   -!- INTERACTION:
CC       P61763; Q17QQ3: SNAP25; NbExp=3; IntAct=EBI-7335973, EBI-7336080;
CC       P61763; P32850: STX1A; NbExp=3; IntAct=EBI-7335973, EBI-7336000;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P61764}. Membrane; Peripheral membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in the retina (at protein level).
CC       {ECO:0000269|PubMed:22039235}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; L26088; AAB41112.1; -; mRNA.
DR   EMBL; AF153327; AAD37018.1; -; mRNA.
DR   PIR; S39346; S39346.
DR   RefSeq; NP_777044.1; NM_174619.3.
DR   AlphaFoldDB; P61763; -.
DR   SMR; P61763; -.
DR   IntAct; P61763; 3.
DR   MINT; P61763; -.
DR   STRING; 9913.ENSBTAP00000050665; -.
DR   iPTMnet; P61763; -.
DR   PaxDb; P61763; -.
DR   PRIDE; P61763; -.
DR   Ensembl; ENSBTAT00000004589; ENSBTAP00000004589; ENSBTAG00000003525.
DR   GeneID; 282378; -.
DR   KEGG; bta:282378; -.
DR   CTD; 6812; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003525; -.
DR   VGNC; VGNC:35445; STXBP1.
DR   eggNOG; KOG1300; Eukaryota.
DR   GeneTree; ENSGT00940000155127; -.
DR   HOGENOM; CLU_009210_2_0_1; -.
DR   InParanoid; P61763; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000003525; Expressed in prefrontal cortex and 103 other tissues.
DR   ExpressionAtlas; P61763; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:AgBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR   GO; GO:0007412; P:axon target recognition; ISS:AgBase.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0016188; P:synaptic vesicle maturation; ISS:AgBase.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Membrane; Phosphoprotein;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..594
FT                   /note="Syntaxin-binding protein 1"
FT                   /id="PRO_0000206276"
FT   MOD_RES         476
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61765"
FT   MOD_RES         509
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08599"
FT   MOD_RES         511
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08599"
FT   MOD_RES         516
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08599"
FT   MOD_RES         593
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61765"
FT   CONFLICT        291
FT                   /note="L -> V (in Ref. 1; AAB41112)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   594 AA;  67569 MW;  2DD0715F875CE0F3 CRC64;
     MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI MTEGITIVED
     INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR AAHVFFTDSC PDALFNELVK
     SRAAKVIKTL TEINIAFLPY ESQVYSLDSA DSFQSFYSPH KAQMKNPILE RLAEQIATLC
     ATLKEYPAVR YRGEYKDNAL LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS
     SPVLHELTFQ AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS
     QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL AEDCMKHYQG
     TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS TYDKIRIILL YIFLKNGITE
     ENLNKLIQHA QIPPEDSEII TNMAHLGVPI VTDSTLRRRS KPERKERISE QTYQLSRWTP
     IIKDIMEDTI EDKLDTKHYP YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF
     ILGGVSLNEM RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS