ID   STXB1_PONAB             Reviewed;         594 AA.
AC   Q5R6D2;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Syntaxin-binding protein 1;
DE   AltName: Full=N-Sec1;
DE   AltName: Full=Protein unc-18 homolog 1;
DE            Short=Unc18-1;
DE   AltName: Full=Protein unc-18 homolog A;
DE            Short=Unc-18A;
GN   Name=STXBP1; Synonyms=UNC18A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the regulation of synaptic vesicle docking
CC       and fusion, possibly through interaction with GTP-binding proteins.
CC       Essential for neurotransmission and binds syntaxin, a component of the
CC       synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact
CC       with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in
CC       determining the specificity of intracellular fusion reactions (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds SYTL4 (By similarity). Interacts with STX1A (By
CC       similarity). Interacts with alpha-synuclein/SNCA; this interaction
CC       controls SNCA self-replicating aggregation (By similarity). Interacts
CC       with CABP5 (By similarity). {ECO:0000250|UniProtKB:P61763,
CC       ECO:0000250|UniProtKB:P61764, ECO:0000250|UniProtKB:P61765}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P61764}. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; CR860559; CAH92684.1; -; mRNA.
DR   RefSeq; NP_001126572.1; NM_001133100.1.
DR   AlphaFoldDB; Q5R6D2; -.
DR   SMR; Q5R6D2; -.
DR   STRING; 9601.ENSPPYP00000021991; -.
DR   Ensembl; ENSPPYT00000022898; ENSPPYP00000021991; ENSPPYG00000019625.
DR   GeneID; 100173563; -.
DR   KEGG; pon:100173563; -.
DR   CTD; 6812; -.
DR   eggNOG; KOG1300; Eukaryota.
DR   GeneTree; ENSGT00940000155127; -.
DR   HOGENOM; CLU_009210_2_0_1; -.
DR   InParanoid; Q5R6D2; -.
DR   OrthoDB; 725424at2759; -.
DR   Proteomes; UP000001595; Chromosome 9.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..594
FT                   /note="Syntaxin-binding protein 1"
FT                   /id="PRO_0000291775"
FT   MOD_RES         476
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61765"
FT   MOD_RES         509
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08599"
FT   MOD_RES         511
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08599"
FT   MOD_RES         516
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08599"
FT   MOD_RES         593
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61765"
SQ   SEQUENCE   594 AA;  67569 MW;  2DD0715F875CE0F3 CRC64;
     MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI MTEGITIVED
     INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR AAHVFFTDSC PDALFNELVK
     SRAAKVIKTL TEINIAFLPY ESQVYSLDSA DSFQSFYSPH KAQMKNPILE RLAEQIATLC
     ATLKEYPAVR YRGEYKDNAL LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS
     SPVLHELTFQ AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS
     QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL AEDCMKHYQG
     TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS TYDKIRIILL YIFLKNGITE
     ENLNKLIQHA QIPPEDSEII TNMAHLGVPI VTDSTLRRRS KPERKERISE QTYQLSRWTP
     IIKDIMEDTI EDKLDTKHYP YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF
     ILGGVSLNEM RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS