ID   STXB2_CANLF             Reviewed;         593 AA.
AC   Q28288;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Syntaxin-binding protein 2;
DE   AltName: Full=Protein unc-18 homolog 2;
DE            Short=Unc18-2;
DE   AltName: Full=Protein unc-18 homolog B;
DE            Short=Unc-18B;
GN   Name=STXBP2;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Cocker spaniel; TISSUE=Kidney;
RX   PubMed=8774707; DOI=10.1111/j.1432-1033.1996.0638u.x;
RA   Riento K., Jaentti J., Jansson S., Hielm S., Lehtonen E., Ehnholm C.,
RA   Keraenen S., Olkkonen V.M.;
RT   "A sec1-related vesicle-transport protein that is expressed predominantly
RT   in epithelial cells.";
RL   Eur. J. Biochem. 239:638-646(1996).
CC   -!- FUNCTION: Involved in the protein trafficking from the Golgi apparatus
CC       to the plasma membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Binds syntaxins 1A, 2, 3 but not 4. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; L41609; AAC00031.1; -; mRNA.
DR   RefSeq; NP_001003216.1; NM_001003216.1.
DR   AlphaFoldDB; Q28288; -.
DR   SMR; Q28288; -.
DR   STRING; 9612.ENSCAFP00000027039; -.
DR   PaxDb; Q28288; -.
DR   PRIDE; Q28288; -.
DR   GeneID; 403880; -.
DR   KEGG; cfa:403880; -.
DR   CTD; 6813; -.
DR   eggNOG; KOG1300; Eukaryota.
DR   HOGENOM; CLU_009210_2_0_1; -.
DR   InParanoid; Q28288; -.
DR   OMA; WPFVSEP; -.
DR   OrthoDB; 725424at2759; -.
DR   TreeFam; TF313242; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0042582; C:azurophil granule; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0042581; C:specific granule; ISS:UniProtKB.
DR   GO; GO:0070820; C:tertiary granule; ISS:UniProtKB.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR   GO; GO:0030348; F:syntaxin-3 binding; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0043312; P:neutrophil degranulation; ISS:UniProtKB.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..593
FT                   /note="Syntaxin-binding protein 2"
FT                   /id="PRO_0000206280"
SQ   SEQUENCE   593 AA;  66500 MW;  BC42120B638FC7E7 CRC64;
     MAPSGLKEVV GEKILNGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED
     INKRREPIPS LEAIYLLSPT EKSVQALIAD FRGTPTFTYK AAHIFFTDTC PEPLFTELSR
     SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RVGERARQIE ALAQQIATLC
     ATLQEYPAIR YRKGPEVTAQ LANAVLAKLN AFKADNPSLG EGPEKTRSQL LIVDRGADPV
     SPLLHELTFQ AMAYDLLNIE QDTYRYETTG LSEAREKAVL LDEDDDLWVE LRHMHIADVS
     KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS
     VEKLCGVEQD LAMGSDTEGE KIKDAMKLIV PVLLDAAVPA YDKIRVLLLY ILLRNGVSEE
     NLAKLIQHAN VQAHSSLIRN LEQLGGTVTN PGGPGTSSRL ERRERLEPTY QLSRWTPVIK
     DVMEDAVEDR LDRKLWPFVS DPAPTSSSQA AVSARFGHWH KNKAGVEMRA GPRLIIYVMG
     GVAMSEMRAA YEVTRATDGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEDI ALP