STXB2_MOUSE
ID STXB2_MOUSE Reviewed; 593 AA.
AC Q64324;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Syntaxin-binding protein 2;
DE AltName: Full=MUSEC1;
DE AltName: Full=Protein unc-18 homolog 2;
DE Short=Munc18-2;
DE Short=Unc18-2;
DE AltName: Full=Protein unc-18 homolog B;
DE Short=Unc-18B;
GN Name=Stxbp2; Synonyms=Unc18b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7890715; DOI=10.1074/jbc.270.11.5857;
RA Tellam J.T., McIntosh S., James D.E.;
RT "Molecular identification of two novel Munc-18 isoforms expressed in non-
RT neuronal tissues.";
RL J. Biol. Chem. 270:5857-5863(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreatic islet;
RX PubMed=7890599; DOI=10.1074/jbc.270.10.4963;
RA Katagiri H., Terasaki J., Murata T., Ishihara H., Ogihara T., Inukai K.,
RA Fukushima Y., Anai M., Kikuchi M., Miyazaki J., Yazaki Y., Oka Y.;
RT "A novel isoform of syntaxin-binding protein homologous to yeast Sec1
RT expressed ubiquitously in mammalian cells.";
RL J. Biol. Chem. 270:4963-4966(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in intracellular vesicle trafficking and vesicle
CC fusion with membranes. Contributes to the granule exocytosis machinery
CC through interaction with soluble N-ethylmaleimide-sensitive factor
CC attachment protein receptor (SNARE) proteins that regulate membrane
CC fusion. Regulates cytotoxic granule exocytosis in natural killer (NK)
CC cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with STX1A, STX2 and STX3. Interacts with STX11.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in testis, intestine, kidney, rat adipose
CC tissue and 3T3-L1 cells.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR EMBL; U19520; AAA69912.1; -; mRNA.
DR EMBL; D42068; BAA07666.1; -; mRNA.
DR EMBL; BC008102; AAH08102.1; -; mRNA.
DR CCDS; CCDS22067.1; -.
DR PIR; A55931; A55931.
DR RefSeq; NP_035633.1; NM_011503.4.
DR AlphaFoldDB; Q64324; -.
DR SMR; Q64324; -.
DR BioGRID; 203565; 13.
DR STRING; 10090.ENSMUSP00000125405; -.
DR iPTMnet; Q64324; -.
DR PhosphoSitePlus; Q64324; -.
DR EPD; Q64324; -.
DR jPOST; Q64324; -.
DR MaxQB; Q64324; -.
DR PaxDb; Q64324; -.
DR PRIDE; Q64324; -.
DR ProteomicsDB; 254772; -.
DR Antibodypedia; 2787; 222 antibodies from 29 providers.
DR DNASU; 20911; -.
DR Ensembl; ENSMUST00000160708; ENSMUSP00000125405; ENSMUSG00000004626.
DR GeneID; 20911; -.
DR KEGG; mmu:20911; -.
DR UCSC; uc009kse.1; mouse.
DR CTD; 6813; -.
DR MGI; MGI:107370; Stxbp2.
DR VEuPathDB; HostDB:ENSMUSG00000004626; -.
DR eggNOG; KOG1300; Eukaryota.
DR GeneTree; ENSGT00940000160045; -.
DR HOGENOM; CLU_009210_2_0_1; -.
DR InParanoid; Q64324; -.
DR OMA; WPFVSEP; -.
DR OrthoDB; 725424at2759; -.
DR PhylomeDB; Q64324; -.
DR TreeFam; TF313242; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR Reactome; R-MMU-449836; Other interleukin signaling.
DR BioGRID-ORCS; 20911; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Stxbp2; mouse.
DR PRO; PR:Q64324; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q64324; protein.
DR Bgee; ENSMUSG00000004626; Expressed in granulocyte and 206 other tissues.
DR ExpressionAtlas; Q64324; baseline and differential.
DR Genevisible; Q64324; MM.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0042582; C:azurophil granule; ISO:MGI.
DR GO; GO:0044194; C:cytolytic granule; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0030027; C:lamellipodium; ISO:MGI.
DR GO; GO:0045335; C:phagocytic vesicle; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0042581; C:specific granule; ISO:MGI.
DR GO; GO:0070820; C:tertiary granule; ISO:MGI.
DR GO; GO:0042589; C:zymogen granule membrane; IDA:MGI.
DR GO; GO:0019905; F:syntaxin binding; ISO:MGI.
DR GO; GO:0017075; F:syntaxin-1 binding; IPI:MGI.
DR GO; GO:0030348; F:syntaxin-3 binding; IPI:MGI.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IDA:MGI.
DR GO; GO:0006887; P:exocytosis; IMP:MGI.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0001909; P:leukocyte mediated cytotoxicity; ISO:MGI.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; ISO:MGI.
DR GO; GO:0043304; P:regulation of mast cell degranulation; ISO:MGI.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR Gene3D; 3.90.830.10; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 1: Evidence at protein level;
KW Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..593
FT /note="Syntaxin-binding protein 2"
FT /id="PRO_0000206282"
SQ SEQUENCE 593 AA; 66357 MW; 1A7735C0566BDC8F CRC64;
MAPLGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED
INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR
SRLAKAVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD ALAQQIATLC
ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV
SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS
VEKLCSVEQD LAMGSDAEGE KIKDAMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE
NLAKLIQHAN VQSYSSLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK
DVMEDVVEDR LDRKLWPFVS DPAPVPSSQA AVSARFGHWH KNKAGVEARA GPRLIVYIVG
GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEGV ALP
