ID   STXB2_PIG               Reviewed;         118 AA.
AC   Q29268;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Syntaxin-binding protein 2;
DE   AltName: Full=Protein unc-18 homolog 2;
DE            Short=Munc18-2;
DE            Short=Unc18-2;
DE   AltName: Full=Protein unc-18 homolog B;
DE            Short=Unc-18B;
DE   Flags: Fragment;
GN   Name=STXBP2; Synonyms=UNC18B;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=8672129; DOI=10.1007/s003359900153;
RA   Winteroe A.K., Fredholm M., Davies W.;
RT   "Evaluation and characterization of a porcine small intestine cDNA library:
RT   analysis of 839 clones.";
RL   Mamm. Genome 7:509-517(1996).
CC   -!- FUNCTION: Involved in intracellular vesicle trafficking and vesicle
CC       fusion with membranes. Contributes to the granule exocytosis machinery
CC       through interaction with soluble N-ethylmaleimide-sensitive factor
CC       attachment protein receptor (SNARE) proteins that regulate membrane
CC       fusion. Regulates cytotoxic granule exocytosis in natural killer (NK)
CC       cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STX1A, STX2 and STX3. Interacts with STX11.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; F14562; CAA23126.1; -; mRNA.
DR   STRING; 9823.ENSSSCP00000014427; -.
DR   PaxDb; Q29268; -.
DR   PeptideAtlas; Q29268; -.
DR   eggNOG; KOG1300; Eukaryota.
DR   InParanoid; Q29268; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   2: Evidence at transcript level;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..>118
FT                   /note="Syntaxin-binding protein 2"
FT                   /id="PRO_0000206283"
FT   NON_TER         118
SQ   SEQUENCE   118 AA;  13033 MW;  0C7AABD850A68DD7 CRC64;
     MAPSGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED
     INKRREPIPS LEAIYLLSPT EKSVQALIXD FRGXPTXTYK AAHVFFTXTC PXPLFSEL