ID   STXB2_RAT               Reviewed;         594 AA.
AC   Q62753;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Syntaxin-binding protein 2;
DE   AltName: Full=Protein unc-18 homolog 2;
DE            Short=Munc18-2;
DE            Short=Unc18-2;
DE   AltName: Full=Protein unc-18 homolog B;
DE            Short=Unc-18B;
GN   Name=Stxbp2; Synonyms=Unc18b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain, and Liver;
RX   PubMed=7768895; DOI=10.1074/jbc.270.22.13022;
RA   Hata Y., Suedhof T.C.;
RT   "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use
RT   of the yeast two-hybrid system to study interactions between proteins
RT   involved in membrane traffic.";
RL   J. Biol. Chem. 270:13022-13028(1995).
CC   -!- FUNCTION: Involved in intracellular vesicle trafficking and vesicle
CC       fusion with membranes. Contributes to the granule exocytosis machinery
CC       through interaction with soluble N-ethylmaleimide-sensitive factor
CC       attachment protein receptor (SNARE) proteins that regulate membrane
CC       fusion. Regulates cytotoxic granule exocytosis in natural killer (NK)
CC       cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STX1A, STX2 and STX3. Interacts with STX11.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U20283; AAA79516.1; -; mRNA.
DR   PIR; A57022; A57022.
DR   RefSeq; NP_112388.1; NM_031126.1.
DR   AlphaFoldDB; Q62753; -.
DR   SMR; Q62753; -.
DR   BioGRID; 249662; 3.
DR   DIP; DIP-289N; -.
DR   IntAct; Q62753; 7.
DR   STRING; 10116.ENSRNOP00000001322; -.
DR   iPTMnet; Q62753; -.
DR   PhosphoSitePlus; Q62753; -.
DR   PaxDb; Q62753; -.
DR   PRIDE; Q62753; -.
DR   GeneID; 81804; -.
DR   KEGG; rno:81804; -.
DR   UCSC; RGD:619967; rat.
DR   CTD; 6813; -.
DR   RGD; 619967; Stxbp2.
DR   eggNOG; KOG1300; Eukaryota.
DR   InParanoid; Q62753; -.
DR   OrthoDB; 725424at2759; -.
DR   PhylomeDB; Q62753; -.
DR   Reactome; R-RNO-114608; Platelet degranulation.
DR   Reactome; R-RNO-449836; Other interleukin signaling.
DR   PRO; PR:Q62753; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0042582; C:azurophil granule; ISO:RGD.
DR   GO; GO:0044194; C:cytolytic granule; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0030027; C:lamellipodium; IDA:RGD.
DR   GO; GO:0045335; C:phagocytic vesicle; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0032991; C:protein-containing complex; IDA:RGD.
DR   GO; GO:0042581; C:specific granule; ISO:RGD.
DR   GO; GO:0070820; C:tertiary granule; ISO:RGD.
DR   GO; GO:0042589; C:zymogen granule membrane; ISO:RGD.
DR   GO; GO:0019905; F:syntaxin binding; IPI:RGD.
DR   GO; GO:0017075; F:syntaxin-1 binding; IPI:RGD.
DR   GO; GO:0030348; F:syntaxin-3 binding; IPI:RGD.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; ISO:RGD.
DR   GO; GO:0006887; P:exocytosis; ISO:RGD.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0001909; P:leukocyte mediated cytotoxicity; ISO:RGD.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0043312; P:neutrophil degranulation; ISO:RGD.
DR   GO; GO:0043306; P:positive regulation of mast cell degranulation; IMP:RGD.
DR   GO; GO:0043304; P:regulation of mast cell degranulation; IMP:RGD.
DR   GO; GO:0010447; P:response to acidic pH; IEP:RGD.
DR   GO; GO:0016079; P:synaptic vesicle exocytosis; TAS:RGD.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   2: Evidence at transcript level;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..594
FT                   /note="Syntaxin-binding protein 2"
FT                   /id="PRO_0000206284"
SQ   SEQUENCE   594 AA;  66696 MW;  B4956372A75F1637 CRC64;
     MAPLGLKAVV VEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED
     INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR
     SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD VLAQQIATLC
     ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV
     SPLLHELTFQ AMAYDLLHIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
     KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS
     VEKLCGVEQD LAMGSDAEGE KIKDTMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE
     NLAKLIQHAN VQSYSNLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK
     DVMEDVVEDR LDRKLWPFVS DPAPVSSSQA AVSSARFGHW HKNKAGIEAR AGPRLIVYIV
     GGVAMSEMRA AYEVTRATEG KWEVLIGSSH ILTPTRFLDD LRTLDQKLED IALP