STXB6_MOUSE
ID STXB6_MOUSE Reviewed; 210 AA.
AC Q8R3T5;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Syntaxin-binding protein 6;
GN Name=Stxbp6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Forms non-fusogenic complexes with SNAP25 and STX1A and may
CC thereby modulate the formation of functional SNARE complexes and
CC exocytosis. {ECO:0000250}.
CC -!- SUBUNIT: Part of a ternary complex containing SNAP25 and STX1A that can
CC be dissociated by NAPA and NSF. Interacts with STX4A (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC024598; AAH24598.1; -; mRNA.
DR CCDS; CCDS25898.1; -.
DR AlphaFoldDB; Q8R3T5; -.
DR SMR; Q8R3T5; -.
DR STRING; 10090.ENSMUSP00000112551; -.
DR iPTMnet; Q8R3T5; -.
DR PhosphoSitePlus; Q8R3T5; -.
DR MaxQB; Q8R3T5; -.
DR PaxDb; Q8R3T5; -.
DR PRIDE; Q8R3T5; -.
DR ProteomicsDB; 258771; -.
DR MGI; MGI:2384963; Stxbp6.
DR eggNOG; KOG1983; Eukaryota.
DR InParanoid; Q8R3T5; -.
DR PhylomeDB; Q8R3T5; -.
DR ChiTaRS; Stxbp6; mouse.
DR PRO; PR:Q8R3T5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8R3T5; protein.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0035542; P:regulation of SNARE complex assembly; IEA:InterPro.
DR GO; GO:0035493; P:SNARE complex assembly; ISS:ParkinsonsUK-UCL.
DR CDD; cd14681; PH-STXBP6; 1.
DR CDD; cd15892; R-SNARE_STXBP6; 1.
DR InterPro; IPR028258; Sec3-PIP2_bind.
DR InterPro; IPR037821; STXBP6_PH.
DR InterPro; IPR037822; STXBP6_SNARE.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF15277; Sec3-PIP2_bind; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR SMART; SM01313; Sec3-PIP2_bind; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8NFX7"
FT CHAIN 2..210
FT /note="Syntaxin-binding protein 6"
FT /id="PRO_0000206783"
FT DOMAIN 151..210
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NFX7"
SQ SEQUENCE 210 AA; 23671 MW; 7C116A9F7FAFC2D8 CRC64;
MSAKSAISKE IFAPLDERML GAVQVKRRTK KKIPFLATGG QGEYLTYICL SVTNKKPTQA
SITKVKQFEG STSFVRRSQW MLEQLRQVNG IDPNRDSAEF DLLFENAFDQ WVASTASEKC
TFFQILHHTC QRYLTDRKPE FINCQSKIMG GNSILHSAAD SVTSAVQKAS QALNERGERL
GRAEEKTEDM KNSAQQFAET AHKLAMKHKC
