ID   STX_APLCA               Reviewed;         290 AA.
AC   Q16932;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Syntaxin;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ganglion;
RA   Hu Y.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potentially involved in docking of synaptic vesicles at
CC       presynaptic active zones. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; U03123; AAA03566.1; -; mRNA.
DR   RefSeq; NP_001191428.1; NM_001204499.1.
DR   AlphaFoldDB; Q16932; -.
DR   SMR; Q16932; -.
DR   GeneID; 100533375; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR   GO; GO:0000149; F:SNARE binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR   GO; GO:0017157; P:regulation of exocytosis; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   CDD; cd00179; SynN; 1.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR028669; STX1.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR006011; Syntaxin_N.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   PANTHER; PTHR19957:SF84; PTHR19957:SF84; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF00804; Syntaxin; 1.
DR   SMART; SM00503; SynN; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Neurotransmitter transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..290
FT                   /note="Syntaxin"
FT                   /id="PRO_0000210238"
FT   TOPO_DOM        1..267
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..290
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          194..256
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          32..114
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   290 AA;  33055 MW;  2F5BF59F164506EA CRC64;
     MTKDRLAALK AAQSDDDDND DVAVTVDSSG FMEEFFEQVD EIREMIDKIA SNVDEVKKKH
     SAILSAPQTD DKMKEELEEL MSEIKKNANK VRAKLKVIEQ NIEQEEHTNK SSADLRIRKT
     QHATLSRKFV EVMNDYNACQ IDYRERCKGR IKRQLAITGK TTTNEELEDM IESGNPAIFT
     QGIIMETQQA NETLADIEAR HNDIMKLETS IRDLHDMFMD MAMLVESQGE MIDRIEYNVE
     QAVDYIETAK MDTKKAVKYQ SKARRKKIMI LVCLAILIII LVGVIGGTLG