ID   STX_DOFAR               Reviewed;          31 AA.
AC   P0DMZ2;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Delta-actitoxin-Dar1b {ECO:0000303|PubMed:22683676};
DE            Short=Delta-AITX-Dar1b {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Da II {ECO:0000303|PubMed:12676443};
DE   Contains:
DE     RecName: Full=Delta-actitoxin-Dar1a {ECO:0000303|PubMed:22683676};
DE              Short=Delta-AITX-Dar1a {ECO:0000303|PubMed:22683676};
DE     AltName: Full=Da I {ECO:0000303|PubMed:12676443};
OS   Dofleinia armata (Armed anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Dofleinia.
OX   NCBI_TaxID=1664552;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX   PubMed=12676443; DOI=10.1016/s0041-0101(02)00368-9;
RA   Honma T., Iso T., Ishida M., Nagashima Y., Shiomi K.;
RT   "Occurrence of type 3 sodium channel peptide toxins in two species of sea
RT   anemones (Dofleinia armata and Entacmaea ramsayi).";
RL   Toxicon 41:637-639(2003).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds specifically to voltage-gated sodium channels (Nav),
CC       thereby delaying their inactivation during signal transduction.
CC       {ECO:0000250|UniProtKB:P09949}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000269|PubMed:12676443}.
CC   -!- MASS SPECTROMETRY: [Delta-actitoxin-Dar1a]: Mass=3089.7; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12676443};
CC   -!- MASS SPECTROMETRY: [Delta-actitoxin-Dar1b]: Mass=3160.0; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12676443};
CC   -!- MISCELLANEOUS: Da I is found as a major form, whereas Da II is found as
CC       a minor form. {ECO:0000269|PubMed:12676443}.
CC   -!- SIMILARITY: Belongs to the sea anemone short toxin (type III) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DMZ2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016330; Neurotoxin_3_Actiniidae.
DR   InterPro; IPR012509; Neurotoxin_3_Anemonia.
DR   Pfam; PF08098; ATX_III; 1.
DR   PIRSF; PIRSF001906; Neurotoxin_III_Actiniidae; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Nematocyst; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   PEPTIDE         1..31
FT                   /note="Delta-actitoxin-Dar1b"
FT                   /id="PRO_0000433701"
FT   PEPTIDE         2..31
FT                   /note="Delta-actitoxin-Dar1a"
FT                   /id="PRO_0000433702"
SQ   SEQUENCE   31 AA;  3170 MW;  26C891E006B6DA37 CRC64;
     AGGKATCCPC FMCSYTAGCP WGQCAHHCGC D