STYK1_HUMAN
ID STYK1_HUMAN Reviewed; 422 AA.
AC Q6J9G0; B2R9T2; Q52LR3; Q9BXY2; Q9NSH1;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 4.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Tyrosine-protein kinase STYK1;
DE EC=2.7.10.2;
DE AltName: Full=Novel oncogene with kinase domain;
DE AltName: Full=Protein PK-unique;
DE AltName: Full=Serine/threonine/tyrosine kinase 1;
GN Name=STYK1; Synonyms=NOK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT GLY-204.
RC TISSUE=Fetal brain;
RX PubMed=12841579; DOI=10.1023/a:1023934017174;
RA Ye X., Ji C., Huang Q., Cheng C., Tang R., Xu J., Zeng L., Dai J., Wu Q.,
RA Gu S., Xie Y., Mao Y.;
RT "Isolation and characterization of a human putative receptor protein kinase
RT cDNA STYK1.";
RL Mol. Biol. Rep. 30:91-96(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Amygdala;
RX PubMed=15150103; DOI=10.1158/0008-5472.can-03-2106;
RA Liu L., Yu X.-Z., Li T.-S., Song L.-X., Chen P.-L., Suo T.-L., Li Y.-H.,
RA Wang S.-D., Chen Y., Ren Y.-M., Zhang S.-P., Chang Z.-J., Fu X.-Y.;
RT "A novel protein tyrosine kinase NOK that shares homology with platelet-
RT derived growth factor/fibroblast growth factor receptors induces
RT tumorigenesis and metastasis in nude mice.";
RL Cancer Res. 64:3491-3499(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-204.
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-204.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLY-204.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-204.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=17298854; DOI=10.1016/j.lungcan.2007.01.002;
RA Amachika T., Kobayashi D., Moriai R., Tsuji N., Watanabe N.;
RT "Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-
RT domain (NOK) in lung cancers.";
RL Lung Cancer 56:337-340(2007).
RN [9]
RP VARIANTS [LARGE SCALE ANALYSIS] GLY-204; TRP-210; SER-237; HIS-379; ILE-395
RP AND LEU-400.
RX PubMed=17344846; DOI=10.1038/nature05610;
RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA Futreal P.A., Stratton M.R.;
RT "Patterns of somatic mutation in human cancer genomes.";
RL Nature 446:153-158(2007).
CC -!- FUNCTION: Probable tyrosine protein-kinase, which has strong
CC transforming capabilities on a variety of cell lines. When
CC overexpressed, it can also induce tumor cell invasion as well as
CC metastasis in distant organs. May act by activating both MAP kinase and
CC phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC -!- INTERACTION:
CC Q6J9G0; P49841: GSK3B; NbExp=2; IntAct=EBI-6424915, EBI-373586;
CC Q6J9G0; P08238: HSP90AB1; NbExp=2; IntAct=EBI-6424915, EBI-352572;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Highly expressed in brain,
CC placenta and prostate. Expressed in tumor cells such as hepatoma cells
CC L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and
CC chronic myelogenous leukemia cells K-562, but not in other tumor cells
CC such as epidermoid carcinoma (A-431). Undetectable in most normal lung
CC tissues, widely expressed in lung cancers.
CC {ECO:0000269|PubMed:12841579, ECO:0000269|PubMed:15150103,
CC ECO:0000269|PubMed:17298854}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AF251059; AAK34949.1; -; mRNA.
DR EMBL; AY563054; AAT01226.1; -; mRNA.
DR EMBL; AK313906; BAG36629.1; -; mRNA.
DR EMBL; AL353940; CAB89250.1; -; mRNA.
DR EMBL; AC021049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471094; EAW96200.1; -; Genomic_DNA.
DR EMBL; BC093822; AAH93822.1; -; mRNA.
DR EMBL; BC093824; AAH93824.1; -; mRNA.
DR CCDS; CCDS8629.1; -.
DR PIR; T48680; T48680.
DR RefSeq; NP_060893.2; NM_018423.2.
DR RefSeq; XP_005253474.1; XM_005253417.2.
DR RefSeq; XP_011519038.1; XM_011520736.1.
DR RefSeq; XP_011519039.1; XM_011520737.2.
DR RefSeq; XP_011519040.1; XM_011520738.2.
DR AlphaFoldDB; Q6J9G0; -.
DR SMR; Q6J9G0; -.
DR BioGRID; 120638; 27.
DR IntAct; Q6J9G0; 27.
DR MINT; Q6J9G0; -.
DR STRING; 9606.ENSP00000075503; -.
DR iPTMnet; Q6J9G0; -.
DR PhosphoSitePlus; Q6J9G0; -.
DR BioMuta; STYK1; -.
DR DMDM; 317373546; -.
DR jPOST; Q6J9G0; -.
DR MassIVE; Q6J9G0; -.
DR PaxDb; Q6J9G0; -.
DR PeptideAtlas; Q6J9G0; -.
DR PRIDE; Q6J9G0; -.
DR ProteomicsDB; 66510; -.
DR TopDownProteomics; Q6J9G0; -.
DR Antibodypedia; 23371; 328 antibodies from 34 providers.
DR DNASU; 55359; -.
DR Ensembl; ENST00000075503.8; ENSP00000075503.3; ENSG00000060140.9.
DR GeneID; 55359; -.
DR KEGG; hsa:55359; -.
DR MANE-Select; ENST00000075503.8; ENSP00000075503.3; NM_018423.3; NP_060893.2.
DR UCSC; uc001qys.2; human.
DR CTD; 55359; -.
DR DisGeNET; 55359; -.
DR GeneCards; STYK1; -.
DR HGNC; HGNC:18889; STYK1.
DR HPA; ENSG00000060140; Tissue enhanced (intestine, prostate, stomach).
DR MIM; 611433; gene.
DR neXtProt; NX_Q6J9G0; -.
DR OpenTargets; ENSG00000060140; -.
DR PharmGKB; PA134976821; -.
DR VEuPathDB; HostDB:ENSG00000060140; -.
DR eggNOG; KOG0200; Eukaryota.
DR GeneTree; ENSGT00940000157871; -.
DR HOGENOM; CLU_000288_7_7_1; -.
DR InParanoid; Q6J9G0; -.
DR OMA; TFLWTCR; -.
DR OrthoDB; 1068299at2759; -.
DR PhylomeDB; Q6J9G0; -.
DR TreeFam; TF316675; -.
DR PathwayCommons; Q6J9G0; -.
DR SignaLink; Q6J9G0; -.
DR SIGNOR; Q6J9G0; -.
DR BioGRID-ORCS; 55359; 11 hits in 1102 CRISPR screens.
DR GeneWiki; STYK1; -.
DR GenomeRNAi; 55359; -.
DR Pharos; Q6J9G0; Tbio.
DR PRO; PR:Q6J9G0; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6J9G0; protein.
DR Bgee; ENSG00000060140; Expressed in endothelial cell and 155 other tissues.
DR ExpressionAtlas; Q6J9G0; baseline and differential.
DR Genevisible; Q6J9G0; HS.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:LIFEdb.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Kinase; Membrane; Nucleotide-binding; Proto-oncogene;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix;
KW Tyrosine-protein kinase.
FT CHAIN 1..422
FT /note="Tyrosine-protein kinase STYK1"
FT /id="PRO_0000088163"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 114..384
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 251
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10028"
FT BINDING 120..128
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 147
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT VARIANT 71
FT /note="R -> G (in dbSNP:rs6650202)"
FT /id="VAR_030766"
FT VARIANT 204
FT /note="S -> G (in dbSNP:rs3759259)"
FT /evidence="ECO:0000269|PubMed:12841579,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17344846, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.6"
FT /id="VAR_022245"
FT VARIANT 210
FT /note="R -> W (in dbSNP:rs34981955)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041841"
FT VARIANT 237
FT /note="L -> S (in dbSNP:rs55877878)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041842"
FT VARIANT 379
FT /note="R -> H (in dbSNP:rs34638573)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041843"
FT VARIANT 395
FT /note="V -> I (in a glioblastoma multiforme sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041844"
FT VARIANT 400
FT /note="V -> L (in dbSNP:rs55766125)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_041845"
FT CONFLICT 192
FT /note="M -> V (in Ref. 1; AAK34949 and 2; AAT01226)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="S -> R (in Ref. 1; AAK34949 and 2; AAT01226)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 422 AA; 47577 MW; AAD45F481BD61C73 CRC64;
MGMTRMLLEC SLSDKLCVIQ EKQYEVIIVP TLLVTIFLIL LGVILWLFIR EQRTQQQRSG
PQGIAPVPPP RDLSWEAGHG GNVALPLKET SVENFLGATT PALAKLQVPR EQLSEVLEQI
CSGSCGPIFR ANMNTGDPSK PKSVILKALK EPAGLHEVQD FLGRIQFHQY LGKHKNLVQL
EGCCTEKLPL YMVLEDVAQG DLLSFLWTCR RDVMTMDGLL YDLTEKQVYH IGKQVLLALE
FLQEKHLFHG DVAARNILMQ SDLTAKLCGL GLAYEVYTRG AISSTQTIPL KWLAPERLLL
RPASIRADVW SFGILLYEMV TLGAPPYPEV PPTSILEHLQ RRKIMKRPSS CTHTMYSIMK
SCWRWREADR PSPRELRLRL EAAIKTADDE AVLQVPELVV PELYAAVAGI RVESLFYNYS
ML
