ID   STYXA_XENLA             Reviewed;         223 AA.
AC   Q4V7N3;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Serine/threonine/tyrosine-interacting protein A;
DE   AltName: Full=Inactive tyrosine-protein phosphatase STYX-A {ECO:0000305};
GN   Name=styx-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytically inactive phosphatase.
CC       {ECO:0000250|UniProtKB:Q8WUJ0}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class subfamily. {ECO:0000305}.
CC   -!- CAUTION: Contains a Gly residue instead of a conserved Cys residue at
CC       position 120 in the dsPTPase catalytic loop which renders it
CC       catalytically inactive as a phosphatase (By similarity). The binding
CC       pocket is however sufficiently preserved to bind phosphorylated
CC       substrates, and may protect them from phosphatases (By similarity).
CC       {ECO:0000250|UniProtKB:Q8WUJ0}.
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DR   EMBL; BC097811; AAH97811.1; -; mRNA.
DR   RefSeq; NP_001089533.1; NM_001096064.1.
DR   AlphaFoldDB; Q4V7N3; -.
DR   SMR; Q4V7N3; -.
DR   PRIDE; Q4V7N3; -.
DR   DNASU; 734588; -.
DR   GeneID; 734588; -.
DR   KEGG; xla:734588; -.
DR   CTD; 734588; -.
DR   Xenbase; XB-GENE-967350; styx.L.
DR   OrthoDB; 1576308at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 734588; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..223
FT                   /note="Serine/threonine/tyrosine-interacting protein A"
FT                   /id="PRO_0000354672"
FT   DOMAIN          28..176
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   223 AA;  25250 MW;  74A7BBA56DBDE449 CRC64;
     MEDVKLQFPS LPLCKEEAED WAYPMRREMQ EILPGLFLGP YSAAMKSKLS VFQKCGITHV
     ICIRQNIEAN FIKPNFQQLF RYLVLDIADN PVENIIRFFP MSKEFIDGCL QTGGKVLIHG
     NAGISRSAAL VIAYIMETFG IKYRDAFTYV QERRFCINPN AGFVHQLQEY EAIYLAKLTI
     KMMSPLQLGR PLCIQSGATG SLKRTLDDED ELGNMQVSAA HEG