ST_POVBA
ID ST_POVBA Reviewed; 172 AA.
AC P15000;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 29-SEP-2021, entry version 89.
DE RecName: Full=Small t antigen;
DE Short=ST;
DE Short=ST-AG;
OS BK polyomavirus (strain AS) (BKPyV).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; Betapolyomavirus.
OX NCBI_TaxID=10631;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2536111; DOI=10.1128/jvi.63.2.901-911.1989;
RA Tavis J.E., Walker D.L., Gardner S.D., Frisque R.J.;
RT "Nucleotide sequence of the human polyomavirus AS virus, an antigenic
RT variant of BK virus.";
RL J. Virol. 63:901-911(1989).
CC -!- FUNCTION: Promotes efficient viral genome replication by accelerating
CC both G1 and S phase progression of the cell cycle. Inhibits host PP2A
CC by binding to the A subunit, thereby displacing lower affinity
CC regulatory B subunit. Inactivation of PP2A in turn results in the
CC transactivation of cyclin A and cyclin D1 promoters. Late during the
CC infection cycle, ST may induce dephosphorylation of host MTOR, leading
CC to the inhibition of cap-dependent translation. May establish and
CC maintain high levels of viral genomes during persistent infection in
CC cell culture. {ECO:0000250|UniProtKB:P03081}.
CC -!- SUBUNIT: Interacts with host PPP2R1A; the interaction inhibits PP2A
CC activity. {ECO:0000250|UniProtKB:P03081}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus
CC {ECO:0000250|UniProtKB:P03081}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Small t antigen;
CC IsoId=P15000-1; Sequence=Displayed;
CC Name=Large T antigen;
CC IsoId=P14999-1; Sequence=External;
CC -!- DOMAIN: The common region of ST and LT proteins comprises the J domain.
CC This domain is essential for multiple viral activities, including
CC virion assembly, viral DNA replication, transformation and
CC transcriptional activation. This domain is also required for cyclin A-
CC transactivating activity of ST. {ECO:0000250|UniProtKB:P03081}.
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DR EMBL; M23122; AAA46883.1; -; Genomic_DNA.
DR PIR; B33278; TVVPSS.
DR SMR; P15000; -.
DR Proteomes; UP000008166; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 1.20.120.1860; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR003354; Papo_T_antigen.
DR InterPro; IPR036092; Papo_T_antigensf.
DR Pfam; PF02380; Papo_T_antigen; 1.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF161240; SSF161240; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 3: Inferred from homology;
KW Acetylation; Activator; Alternative splicing; Early protein;
KW Host cytoplasm; Host nucleus; Host-virus interaction; Metal-binding;
KW Oncogene; Phosphoprotein; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..172
FT /note="Small t antigen"
FT /id="PRO_0000115052"
FT DOMAIN 12..75
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT ZN_FING 101..114
FT /note="C4-type; atypical"
FT ZN_FING 120..141
FT /note="H1C3-type; atypical"
FT MOD_RES 1
FT /note="N-acetylmethionine; by host"
FT /evidence="ECO:0000250|UniProtKB:P03081"
SQ SEQUENCE 172 AA; 20454 MW; 0AB1BE041D1F302D CRC64;
MDKVLNREES MELMDLLGLE RAAWGNLPLM RKAYLKKCKE FHPDKGGDED KMKRMNTLYK
KMEQDVKVAH QPDFGTWNSS EVCADFPLCP DTLYCKEWPI CSKKPSVHCP CMLCQLRLRH
LNRKFLRKEP LVWIDCYCID CFTQWFGLDL TEETLQWWVQ IIGETPFRDL KL