ST_POVLY
ID ST_POVLY Reviewed; 189 AA.
AC P04009;
DT 23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-1986, sequence version 1.
DT 23-FEB-2022, entry version 95.
DE RecName: Full=Small t antigen;
DE Short=ST;
DE Short=ST-AG;
OS B-lymphotropic polyomavirus (LPV).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; unclassified Polyomaviridae.
OX NCBI_TaxID=332091;
OH NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2998001; DOI=10.1016/0042-6822(85)90108-4;
RA Pawlita M., Clad A., zur Hausen H.;
RT "Complete DNA sequence of lymphotropic papovavirus: prototype of a new
RT species of the polyomavirus genus.";
RL Virology 143:196-211(1985).
RN [2]
RP SEQUENCE REVISION.
RA Pawlita M., Clad A., zur Hausen H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3495678; DOI=10.7883/yoken1952.39.151;
RA Furuno A., Kanda T., Yoshiike K.;
RT "Monkey B-lymphotropic papovavirus genome: the entire DNA sequence and
RT variable regions.";
RL Jpn. J. Med. Sci. Biol. 39:151-161(1986).
CC -!- FUNCTION: Promotes efficient viral genome replication by accelerating
CC both G1 and S phase progression of the cell cycle. Inhibits host PP2A
CC by binding to the A subunit, thereby displacing lower affinity
CC regulatory B subunit. Inactivation of PP2A in turn results in the
CC transactivation of cyclin A and cyclin D1 promoters. Late during the
CC infection cycle, ST may induce dephosphorylation of host MTOR, leading
CC to the inhibition of cap-dependent translation. May establish and
CC maintain high levels of viral genomes during persistent infection in
CC cell culture. {ECO:0000250|UniProtKB:P03081}.
CC -!- SUBUNIT: Interacts with host PPP2R1A; the interaction inhibits PP2A
CC activity. {ECO:0000250|UniProtKB:P03081}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus
CC {ECO:0000250|UniProtKB:P03081}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Small t antigen;
CC IsoId=P04009-1; Sequence=Displayed;
CC Name=Large T antigen;
CC IsoId=P04008-1; Sequence=External;
CC -!- DOMAIN: The common region of ST and LT proteins comprises the J domain.
CC This domain is essential for multiple viral activities, including
CC virion assembly, viral DNA replication, transformation and
CC transcriptional activation. This domain is also required for cyclin A-
CC transactivating activity of ST. {ECO:0000250|UniProtKB:P03081}.
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DR EMBL; K02562; AAA47063.2; -; Genomic_DNA.
DR EMBL; M30540; AAA47066.1; -; Genomic_DNA.
DR PIR; A03617; TVVPAL.
DR RefSeq; NP_848009.2; NC_004763.2.
DR SMR; P04009; -.
DR GeneID; 1494438; -.
DR KEGG; vg:1494438; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 1.20.120.1860; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR003354; Papo_T_antigen.
DR InterPro; IPR036092; Papo_T_antigensf.
DR Pfam; PF02380; Papo_T_antigen; 1.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF161240; SSF161240; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 3: Inferred from homology;
KW Acetylation; Activator; Alternative splicing; Early protein;
KW Host cytoplasm; Host nucleus; Host-virus interaction; Metal-binding;
KW Oncogene; Phosphoprotein; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..189
FT /note="Small t antigen"
FT /id="PRO_0000115057"
FT DOMAIN 12..75
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT ZN_FING 111..124
FT /note="C4-type; atypical"
FT ZN_FING 130..152
FT /note="H1C3-type; atypical"
FT MOD_RES 1
FT /note="N-acetylmethionine; by host"
FT /evidence="ECO:0000250|UniProtKB:P03081"
SQ SEQUENCE 189 AA; 22171 MW; 448F6E934A29F068 CRC64;
MDQTLSKEER NELMDLLQIT RAAWGNLSMM KKAYKNVSKL YHPDKGGDSA KMQRLNELFQ
RVQVTLMEIR SQCGSSSSQV AWFFWDENFR TLGAFLGEKF NEKIIGLYPT CTKFVRANCN
CIVCLLKKQH AGTKKNLKKP CLVWGECWCY KCYLVWFGFP EDFTSFRYWT LLMANMDLSM
LKLWTELGF