ID   ST_POVS1                Reviewed;         172 AA.
AC   Q3L6L4; Q1W5W9;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   29-SEP-2021, entry version 73.
DE   RecName: Full=Small t antigen;
DE            Short=ST;
DE            Short=ST-AG;
OS   Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Sepolyvirales; Polyomaviridae; unclassified Polyomaviridae.
OX   NCBI_TaxID=557605;
OH   NCBI_TaxID=36229; Papio hamadryas ursinus (Chacma baboon).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SA12;
RX   PubMed=16189011; DOI=10.1128/jvi.79.20.13094-13104.2005;
RA   Cantalupo P., Doering A., Sullivan C.S., Pal A., Peden K.W., Lewis A.M.,
RA   Pipas J.M.;
RT   "Complete nucleotide sequence of polyomavirus SA12.";
RL   J. Virol. 79:13094-13104(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16731904; DOI=10.1128/jvi.00056-06;
RA   Perez-Losada M., Christensen R.G., McClellan D.A., Adams B.J.,
RA   Viscidi R.P., Demma J.C., Crandall K.A.;
RT   "Comparing phylogenetic codivergence between polyomaviruses and their
RT   hosts.";
RL   J. Virol. 80:5663-5669(2006).
CC   -!- FUNCTION: Promotes efficient viral genome replication by accelerating
CC       both G1 and S phase progression of the cell cycle. Inhibits host PP2A
CC       by binding to the A subunit, thereby displacing lower affinity
CC       regulatory B subunit. Inactivation of PP2A in turn results in the
CC       transactivation of cyclin A and cyclin D1 promoters. Late during the
CC       infection cycle, ST may induce dephosphorylation of host MTOR, leading
CC       to the inhibition of cap-dependent translation. May establish and
CC       maintain high levels of viral genomes during persistent infection in
CC       cell culture. {ECO:0000250|UniProtKB:P03081}.
CC   -!- SUBUNIT: Interacts with host PPP2R1A; the interaction inhibits PP2A
CC       activity. {ECO:0000250|UniProtKB:P03081}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus
CC       {ECO:0000250|UniProtKB:P03081}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Small t antigen;
CC         IsoId=Q3L6L4-1; Sequence=Displayed;
CC       Name=Large T antigen;
CC         IsoId=Q3L6L5-1; Sequence=External;
CC   -!- DOMAIN: The common region of ST and LT proteins comprises the J domain.
CC       This domain is essential for multiple viral activities, including
CC       virion assembly, viral DNA replication, transformation and
CC       transcriptional activation. This domain is also required for cyclin A-
CC       transactivating activity of ST. {ECO:0000250|UniProtKB:P03081}.
CC   -!- MISCELLANEOUS: [Isoform Small t antigen]: Produced by alternative
CC       splicing.
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DR   EMBL; AY614708; AAV75980.1; -; Genomic_DNA.
DR   EMBL; DQ435829; ABD92878.1; -; Genomic_DNA.
DR   RefSeq; YP_406556.1; NC_007611.1.
DR   SMR; Q3L6L4; -.
DR   GeneID; 5123719; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   Gene3D; 1.20.120.1860; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR003354; Papo_T_antigen.
DR   InterPro; IPR036092; Papo_T_antigensf.
DR   Pfam; PF02380; Papo_T_antigen; 1.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF161240; SSF161240; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   3: Inferred from homology;
KW   Acetylation; Activator; Alternative splicing; Early protein;
KW   Host cytoplasm; Host nucleus; Host-virus interaction; Metal-binding;
KW   Oncogene; Phosphoprotein; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..172
FT                   /note="Small t antigen"
FT                   /id="PRO_0000356266"
FT   DOMAIN          12..75
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   ZN_FING         101..114
FT                   /note="C4-type; atypical"
FT   ZN_FING         120..141
FT                   /note="H1C3-type; atypical"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P03081"
SQ   SEQUENCE   172 AA;  20420 MW;  611EE07C41360E0A CRC64;
     MDKVLNREES MELMDLLGLE RAAWGNLPLM RKAYLRKCKE FHPDKGGDED KMKRMNTLYK
     KMEQDVKVAH QPDFGAWHSS EVGSDFPPCP DTLYCKDWPL CATKPSAHCP CMLCQLRNKH
     VYRKFLRRDP LVWIDCYCFD CFRQWFGLDL NEEALLWWSH IIGETPFRDL KL