SUB2A_COCP7
ID SUB2A_COCP7 Reviewed; 406 AA.
AC C5P6D1;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Subtilisin-like protease CPC735_023170;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN ORFNames=CPC735_023170;
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Secreted subtilisin-like serine protease with keratinolytic
CC activity that contributes to pathogenicity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR EMBL; ACFW01000025; EER26981.1; -; Genomic_DNA.
DR RefSeq; XP_003069126.1; XM_003069080.1.
DR AlphaFoldDB; C5P6D1; -.
DR SMR; C5P6D1; -.
DR EnsemblFungi; EER26981; EER26981; CPC735_023170.
DR GeneID; 9694621; -.
DR KEGG; cpw:CPC735_023170; -.
DR VEuPathDB; FungiDB:CPC735_023170; -.
DR HOGENOM; CLU_011263_1_4_1; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 3.30.70.80; -; 1.
DR Gene3D; 3.40.50.200; -; 1.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; SSF52743; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Hydrolase; Protease; Secreted; Serine protease; Signal;
KW Virulence; Zymogen.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..118
FT /evidence="ECO:0000250"
FT /id="PRO_0000407006"
FT CHAIN 119..406
FT /note="Subtilisin-like protease CPC735_023170"
FT /id="PRO_0000407007"
FT DOMAIN 35..115
FT /note="Inhibitor I9"
FT /evidence="ECO:0000255"
FT DOMAIN 127..406
FT /note="Peptidase S8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT REGION 283..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 161
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 192
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 351
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 346
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 402
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 406 AA; 43287 MW; E08262932E5BEBC0 CRC64;
MRLFQSTCVL VGTVLPLFTA FPISSPREIE IIPDKYIITF KKGIDQAAIE AHTAWVSSVQ
ARNTARGFTT AETPGLERMF SIHNFNAYSG SFDRETIEEI RSHPNVESVE PDSMAYVTEL
IEQRNATYGP RRISHREIPT GDNSYWYDSK AGEGSFVYIM DTGINKAHVD FEGRAIPGVN
LHDVAFDDTH GHGSHCAGIA GSKTYGVAKK ATIVDVKVFT RGGGAWSLLM GGLDWSVKNI
TGEDRQAKSA VSISISGPTN QAMNNAVKAA VEAGVTVVVA SGNDGRDAGR NSPGSAPESI
TVGSINSRRG MDTRSSFSNY GSSVAIHAPG EGIISTYKGS RDATANMSGT SMAAPHVAGL
IAYLQSIHDL PDPAAARRKL LELATSDKIQ DVRGSANKLA YNGSGK
