ID   SUB4_TRIEQ              Reviewed;         394 AA.
AC   A7UKV6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Subtilisin-like protease 4;
DE            EC=3.4.21.-;
DE   Flags: Precursor; Fragment;
GN   Name=SUB4;
OS   Trichophyton equinum (Horse ringworm fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=63418;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Brown J.T., Preuett B.L., Abdel-Rahman S.M.;
RT   "Comparing putative pathogenicity factors between Trichophyton tonsurans
RT   and Trichophyton equinum.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Secreted subtilisin-like serine protease with keratinolytic
CC       activity that contributes to pathogenicity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR   EMBL; EU076571; ABU50381.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7UKV6; -.
DR   SMR; A7UKV6; -.
DR   MEROPS; S08.115; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Protease; Secreted; Serine protease; Signal;
KW   Virulence; Zymogen.
FT   SIGNAL          <1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..116
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000380788"
FT   CHAIN           117..>394
FT                   /note="Subtilisin-like protease 4"
FT                   /id="PRO_0000380789"
FT   DOMAIN          36..115
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          126..394
FT                   /note="Peptidase S8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        158
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        189
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        344
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        250
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        306
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         394
SQ   SEQUENCE   394 AA;  41614 MW;  1CCD1717DE699DC8 CRC64;
     CLKTLSVFLA AFAAADARAV FKTQGHKNSE MIPDNYIVVM KDGVSQDDFK AHVSSVASIH
     STNKAKRGTN TEGMKREFDI MNWRGYHGHF DRDTLEEILN DSKVDYVEQD QVVRISGLVT
     QRGAPSWGLG RVSHRQAGSR DYVFDDSAGR GVTIYGVDTG IDINHQDFRG RARWGTNTAD
     RDNADRHGHG THTASTFAGT AYGIAKNANI VAVKVLSSDG SGSTSGIIAG INYCVQDAQQ
     RGILGKAAMN LSLGGGFSQA NNDAVTRAQN AGIFVAVAAG NDNRDARNYS PASAPAVCTV
     ASSTINDSKS SFSNWGPVVD IYAPGSDIIA ARPGGGSTTM SGTSMASPHV AGMGAYMIGL
     GADPRSLCDR LKQLATPAIR NPGSSTTNRL LYNG