ID   SUB6_TRISH              Reviewed;         405 AA.
AC   Q8J077;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Subtilisin-like protease 6;
DE            EC=3.4.21.-;
DE   AltName: Allergen=Tri m 2;
DE   Flags: Precursor; Fragment;
GN   Name=SUB6; Synonyms=tri m 2;
OS   Trichophyton schoenleinii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=34386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 433.63, VKPGF 232/181, and VKPGF 235/25;
RA   Probst S., Polyakov I., Ivanova L., Graeser Y.;
RT   "Development of DNA markers to explore the genetic relatedness of strains
RT   of the two dermatophyte species causing Favus of human and mouse.";
RL   Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Secreted subtilisin-like serine protease with keratinolytic
CC       activity that contributes to pathogenicity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR   EMBL; AJ430841; CAD23616.1; -; Genomic_DNA.
DR   EMBL; AJ430842; CAD23617.1; -; Genomic_DNA.
DR   EMBL; AJ430843; CAD23618.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8J077; -.
DR   SMR; Q8J077; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   1: Evidence at protein level;
KW   Allergen; Glycoprotein; Hydrolase; Protease; Secreted; Serine protease;
KW   Signal; Virulence; Zymogen.
FT   SIGNAL          <1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..125
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000397800"
FT   CHAIN           126..>405
FT                   /note="Subtilisin-like protease 6"
FT                   /id="PRO_0000397801"
FT   DOMAIN          34..118
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          133..405
FT                   /note="Peptidase S8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        165
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        196
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        356
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        124
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        250
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        262
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         405
SQ   SEQUENCE   405 AA;  42263 MW;  AA0ABC90FF68004F CRC64;
     FITKAIPIVL AALSAVNGAK ILEAGPHAET IPNKYIVVMK KDVSDEAFST HTTWLSQNLN
     RRLMRRSGSS KAMAGMQNKY SLGGIFRAYS GEFDDAMIKD ISNHDDVDYI EPDFVVRTST
     NGTNLTRQEN VPSWGLARVG SKQAGGTTYY YDSSAGKGVT AYVIDTGIDI EHEDFGGRAK
     WGKNFVDQRD EDCNGHGTHV AGTVGGTKYG LAKSVSLVAV KVLDCDGSGS NSGVIRGMEW
     AMREASGGGN GTAKAAGKSV MNMSLGGPRS QASNDAARAI SEAGIFMAVA AGNENMDAQH
     SSPASEPSVC TVAASTEDDG KAEFSNYGAV VDVYAPGKDI TSLKPGGSTD TLSGTSMASP
     HVCGLGAYLI GLGKQGGPGL CDTIKQMANE AIQRPGEGTT GKLIY