ABIA_DICDI
ID ABIA_DICDI Reviewed; 332 AA.
AC Q55FT9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Abl interactor homolog;
GN Name=abiA; ORFNames=DDB_G0267956;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION IN THE WAVE COMPLEX, INTERACTION WITH SCRA, AND FUNCTION.
RX PubMed=17314411; DOI=10.1091/mbc.e06-06-0518;
RA Caracino D., Jones C., Compton M., Saxe C.L. III;
RT "The N-terminus of Dictyostelium Scar interacts with Abi and HSPC300 and is
RT essential for proper regulation and function.";
RL Mol. Biol. Cell 18:1609-1620(2007).
RN [3]
RP IDENTIFICATION IN THE WAVE COMPLEX, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=18261908; DOI=10.1016/j.cub.2008.01.026;
RA Pollitt A.Y., Insall R.H.;
RT "Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE
RT complex in cytokinesis.";
RL Curr. Biol. 18:203-210(2008).
CC -!- FUNCTION: Involved in regulation of actin and microtubule organization.
CC Required for proper cytokinesis. {ECO:0000269|PubMed:17314411,
CC ECO:0000269|PubMed:18261908}.
CC -!- SUBUNIT: Part of a Scar/WAVE complex containing brk1, scrA, abiA, pirA
CC and napA. Interacts with scrA. {ECO:0000269|PubMed:17314411,
CC ECO:0000269|PubMed:18261908}.
CC -!- INTERACTION:
CC Q55FT9; Q54NF8: scrA; NbExp=3; IntAct=EBI-1808197, EBI-1808146;
CC -!- DISRUPTION PHENOTYPE: Cells show no developmental defects, mild
CC motility defects and serious defects in cytokinesis.
CC {ECO:0000269|PubMed:18261908}.
CC -!- SIMILARITY: Belongs to the ABI family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73431.1; -; Genomic_DNA.
DR RefSeq; XP_647444.1; XM_642352.1.
DR AlphaFoldDB; Q55FT9; -.
DR SMR; Q55FT9; -.
DR IntAct; Q55FT9; 2.
DR STRING; 44689.DDB0231426; -.
DR PaxDb; Q55FT9; -.
DR EnsemblProtists; EAL73431; EAL73431; DDB_G0267956.
DR GeneID; 8616251; -.
DR KEGG; ddi:DDB_G0267956; -.
DR dictyBase; DDB_G0267956; abiA.
DR eggNOG; KOG2546; Eukaryota.
DR HOGENOM; CLU_837893_0_0_1; -.
DR InParanoid; Q55FT9; -.
DR OMA; DQMVNMH; -.
DR Reactome; R-DDI-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-DDI-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013404; RAC2 GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR PRO; PR:Q55FT9; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0031252; C:cell leading edge; IC:dictyBase.
DR GO; GO:0005911; C:cell-cell junction; IC:dictyBase.
DR GO; GO:0032433; C:filopodium tip; IC:dictyBase.
DR GO; GO:0031143; C:pseudopodium; IC:dictyBase.
DR GO; GO:0031209; C:SCAR complex; IDA:dictyBase.
DR GO; GO:0017124; F:SH3 domain binding; IBA:GO_Central.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0043326; P:chemotaxis to folate; IMP:dictyBase.
DR GO; GO:0045184; P:establishment of protein localization; IMP:dictyBase.
DR GO; GO:0046847; P:filopodium assembly; IMP:dictyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR GO; GO:0031269; P:pseudopodium assembly; IMP:dictyBase.
DR GO; GO:0008064; P:regulation of actin polymerization or depolymerization; TAS:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR InterPro; IPR028457; ABI.
DR PANTHER; PTHR10460; PTHR10460; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Coiled coil; Reference proteome.
FT CHAIN 1..332
FT /note="Abl interactor homolog"
FT /id="PRO_0000331387"
FT REGION 152..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..104
FT /evidence="ECO:0000255"
FT COMPBIAS 152..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..249
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..332
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 35313 MW; 0EBD2BE771A2D7DD CRC64;
MSESIDINVY SQTTIPNAMA ELMDNHNKME QISAYCKSLY ANGDAAQAYE QTQGYAKNAL
LNVAYHIQTV GTHITSLLQL QTNEMEKLNI EIQTLTQRVR MIHDSTGTNV FSNQDAAKPY
KSSLKNRKVD TEATKAPVKY VHKPISYGIS ASDINQNGVP PPLNHSNSSA NLTSSSGHLA
ASSTSNSSTP SYQSPSYSSQ PTISSGTPPP IQKQPPRVGN APPPPSLSVP AAPPPPVMNV
PPPPPTSQRP SSVNNNAPSN DFPPPPPPSS SSSGGDLPPP PSFGLPPPPT LGDDFPPPPP
PPVGSYDFPP PPARPQSQFY DHNDFPPPPP PM
