SUC6_ARATH
ID SUC6_ARATH Reviewed; 492 AA.
AC Q6A329; Q9FIX9;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Putative sucrose transport protein SUC6;
DE AltName: Full=Sucrose permease 6;
DE AltName: Full=Sucrose-proton symporter 6;
GN Name=SUC6; Synonyms=SUC13; OrderedLocusNames=At5g43610; ORFNames=K9D7.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. C24;
RA Sauer N., Ludwig A., Knoblauch A., Klebl F.;
RT "SNPs and splicing variants of sucrose transporter genes in different
RT ecotypes of Arabidopsis thaliana.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be responsible for the transport of glucosides into the
CC cell, with the concomitant uptake of protons (symport system). Does not
CC seem to transport sucrose.
CC -!- PATHWAY: Glycan biosynthesis; sucrose metabolism.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2.4) family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AJ604565; CAE53179.1; -; mRNA.
DR EMBL; AB016875; BAB11624.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94987.1; -; Genomic_DNA.
DR RefSeq; NP_199174.1; NM_123727.2.
DR AlphaFoldDB; Q6A329; -.
DR BioGRID; 19631; 2.
DR STRING; 3702.AT5G43610.1; -.
DR PaxDb; Q6A329; -.
DR PRIDE; Q6A329; -.
DR ProteomicsDB; 245229; -.
DR EnsemblPlants; AT5G43610.1; AT5G43610.1; AT5G43610.
DR GeneID; 834381; -.
DR Gramene; AT5G43610.1; AT5G43610.1; AT5G43610.
DR KEGG; ath:AT5G43610; -.
DR Araport; AT5G43610; -.
DR TAIR; locus:2158352; AT5G43610.
DR eggNOG; KOG0637; Eukaryota.
DR HOGENOM; CLU_025234_3_0_1; -.
DR InParanoid; Q6A329; -.
DR OMA; MLINACA; -.
DR OrthoDB; 1230185at2759; -.
DR PhylomeDB; Q6A329; -.
DR UniPathway; UPA00238; -.
DR Proteomes; UP000006548; Chromosome 5.
DR Genevisible; Q6A329; AT.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0008506; F:sucrose:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005985; P:sucrose metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005989; Suc_symporter_pln.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR01301; GPH_sucrose; 1.
PE 5: Uncertain;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome;
KW Sugar transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..492
FT /note="Putative sucrose transport protein SUC6"
FT /id="PRO_0000122527"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..139
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..224
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..324
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..403
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..446
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..469
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 491..492
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q39232"
FT CONFLICT 21
FT /note="S -> A (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="S -> P (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="M -> T (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 175
FT /note="K -> T (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="A -> G (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="Y -> H (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 342
FT /note="F -> C (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 383
FT /note="E -> G (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="R -> K (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="L -> F (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="A -> V (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 423
FT /note="A -> V (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 426..428
FT /note="SII -> FIN (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 446
FT /note="T -> A (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
FT CONFLICT 479
FT /note="A -> T (in Ref. 1; CAE53179)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 492 AA; 52727 MW; 1243E17829A07C90 CRC64;
MSDLQANKDA AAVNRQSSSS SADLNGPSPM RKMISVASIA AGIQFGWALQ LSLLTPYVQL
LGVPHKWSSF IWLCGPVSGL LVQPSVGYFS DRCKSRFGRR RPFIAMGALL VAVAVVLIGY
AADFGHSMGD KVDEPVKMRA VVIFALGFWI LDVANNTLQG PCRAFLGDLA AGDAKKTRTA
NAFFSFFMAV GNVLGYAAGS YTNLYKIFPF TMTKACDIYC ANLKSCFFLS ITLLLVVTII
ALWYVEDKQW SPKADSDNEK TPFFGEIFGA FKVMKRPMWM LLIVTALNWI AWFPFLLYDT
DWMGREVYGG DSKGDDKMKK LYNQGIHVGG LGLMLNSIVL GFMSLGIEGI SRKMGGAKRL
WGAVNIILAV CLAMTVLVTK KAEEHRRIAG PMALPTDGIR AGALTLFALL GIPLAITFSI
PFALASIISS SSGAGQGLSL GVLNMTIVIP QMVVSFGVGP IDALFGGGNL PGFVVGAIAA
AISSVVAFSV LP
