SUC7_ARATH
ID SUC7_ARATH Reviewed; 491 AA.
AC Q67YF8; Q058N2; Q9C6H8; Q9C716;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Sucrose transport protein SUC7;
DE AltName: Full=Sucrose permease 7;
DE AltName: Full=Sucrose-proton symporter 7;
GN Name=SUC7; OrderedLocusNames=At1g66570; ORFNames=F28G11.1, T12I7.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15361146; DOI=10.1111/j.1365-313x.2004.02196.x;
RA Sauer N., Ludwig A., Knoblauch A., Rothe P., Gahrtz M., Klebl F.;
RT "AtSUC8 and AtSUC9 encode functional sucrose transporters, but the closely
RT related AtSUC6 and AtSUC7 genes encode aberrant proteins in different
RT Arabidopsis ecotypes.";
RL Plant J. 40:120-130(2004).
CC -!- FUNCTION: May be responsible for the transport of glucosides into the
CC cell, with the concomitant uptake of protons (symport system). Does not
CC seem to transport sucrose.
CC -!- PATHWAY: Glycan biosynthesis; sucrose metabolism.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q67YF8-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in anthers.
CC {ECO:0000269|PubMed:15361146}.
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2.4) family. {ECO:0000305}.
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DR EMBL; AC074025; AAG51155.1; -; Genomic_DNA.
DR EMBL; AC079285; AAG51172.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34528.1; -; Genomic_DNA.
DR EMBL; AK176510; BAD44273.1; -; mRNA.
DR EMBL; BT029186; ABJ17121.1; -; mRNA.
DR PIR; E96691; E96691.
DR RefSeq; NP_176830.1; NM_105328.3. [Q67YF8-1]
DR AlphaFoldDB; Q67YF8; -.
DR BioGRID; 28196; 4.
DR IntAct; Q67YF8; 2.
DR STRING; 3702.AT1G66570.1; -.
DR PaxDb; Q67YF8; -.
DR ProteomicsDB; 245354; -. [Q67YF8-1]
DR EnsemblPlants; AT1G66570.1; AT1G66570.1; AT1G66570. [Q67YF8-1]
DR GeneID; 842975; -.
DR Gramene; AT1G66570.1; AT1G66570.1; AT1G66570. [Q67YF8-1]
DR KEGG; ath:AT1G66570; -.
DR Araport; AT1G66570; -.
DR TAIR; locus:2028947; AT1G66570.
DR eggNOG; KOG0637; Eukaryota.
DR HOGENOM; CLU_025234_3_0_1; -.
DR InParanoid; Q67YF8; -.
DR OMA; ITANWIT; -.
DR OrthoDB; 1230185at2759; -.
DR PhylomeDB; Q67YF8; -.
DR UniPathway; UPA00238; -.
DR PRO; PR:Q67YF8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q67YF8; baseline and differential.
DR Genevisible; Q67YF8; AT.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0008506; F:sucrose:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005985; P:sucrose metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005989; Suc_symporter_pln.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR01301; GPH_sucrose; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Phosphoprotein;
KW Reference proteome; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..491
FT /note="Sucrose transport protein SUC7"
FT /id="PRO_0000122528"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..180
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..276
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..323
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..443
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 465..468
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 490..491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q39232"
FT CONFLICT 279
FT /note="M -> V (in Ref. 3; BAD44273)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 491 AA; 52873 MW; 3B6CDBA1C9FAAE8B CRC64;
MSDLQANKDE TTVDRQSSSS VDLDGPSPLR KMISVASIAA GIQFGWALQL SLLTPYVQLL
GVPHKWPSFI WLCGPVSGLL VQPSVGYFSD RCTSRFGRRR PFIATGALLV AVSVVLIGYA
ADFGHSMGDK IDKPVKMRAV VIFALGFWIL DVANNTLQGP CRAFLGDLAA GDAQKTRTAN
AFFSFFMAVG NVLGYAAGSY TNLYKIFPFT MTKACDIYCA NLKSCFFLSI TLLLVVTIIA
LWYVEDKQWS PKADSDNEKT PFFGEIFGAF KVMKRPMWML LIVTALNWIA WFPFLLYDTD
WMGREVYGGD SKGDDKMKKL YNQGIHVGAL GLMLNSIVLG VMSLGIEGIS RKMGGAKRLW
GAVNIILAVC LAMTVLVTKK AEEHRRIAGP MALPTDGIRA GALTLFALLG IPLAITFSIP
FALASIISSS SGAGQRLSLG VLNMAIVIPQ MIVSFGVGPI DALFGDGNLP GFVVGAIAAA
VSSIVAFTVL P
