ID   ABIG2_LACLC             Reviewed;         397 AA.
AC   Q48726;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Abortive phage resistance protein AbiGii;
GN   Name=abiGII;
OS   Lactococcus lactis subsp. cremoris (Streptococcus cremoris).
OG   Plasmid pCI750.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1359;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=UC653;
RX   PubMed=8795193; DOI=10.1128/aem.62.9.3075-3082.1996;
RA   O'Connor L., Coffey A., Daly C., Fitzgerald G.F.;
RT   "AbiG, a genotypically novel abortive infection mechanism encoded by
RT   plasmid pCI750 of Lactococcus lactis subsp. cremoris UC653.";
RL   Appl. Environ. Microbiol. 62:3075-3082(1996).
RN   [2]
RP   EFFECT ON PHAGES.
RX   PubMed=9872803; DOI=10.1128/aem.65.1.330-335.1999;
RA   O'Connor L., Tangney M., Fitzgerald G.F.;
RT   "Expression, regulation, and mode of action of the AbiG abortive infection
RT   system of Lactococcus lactis subsp. cremoris UC653.";
RL   Appl. Environ. Microbiol. 65:330-335(1999).
CC   -!- FUNCTION: Confers resistance to phages by a mechanism of abortive
CC       infection. Seems to act by interfering with phage RNA synthesis. Does
CC       not act at the level of phage DNA synthesis.
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DR   EMBL; U60336; AAB38313.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q48726; -.
DR   PRIDE; Q48726; -.
DR   InterPro; IPR031707; AbiGii_2.
DR   Pfam; PF16873; AbiGii_2; 1.
PE   4: Predicted;
KW   Plasmid.
FT   CHAIN           1..397
FT                   /note="Abortive phage resistance protein AbiGii"
FT                   /id="PRO_0000064426"
SQ   SEQUENCE   397 AA;  46054 MW;  62D8AF4BD59DC3B3 CRC64;
     MAKSKFKTTF SNDKATTSST ALLKYINKKA PKGYKYEILY KGSDIYSLKK DNTDEKISFL
     VRFKFPLNFE GIKVTNPQDL LELSYRTQKE IVLDETLQNG SDGQPPTLVS LKGEVGKQSI
     FPIPFPKLDP IKLEWFGGAL EIPIKRIPYA SLSEIKLESE SDNILHVSFL FNETNNKVHL
     NTNINFEYLR TIDDYFKFRD FLKNYSEGRV KILSKNITLR SEDNNDKIKI FEKNDKLYNA
     LRLIQSKIDT KIPFPQNLSI KDVNIIKILF ESYINDRVVK FKSEPSLKFT FDDSSNFKES
     FPITGKKNMG IFVPFQRNIK FLSVSIPIIE NQLYTDTTVK TADLQDRVLI LETNKNNESF
     VFYQNSEEYK EISINEMLEK KKAAIELDDI DFSVLKK