ABIL2_ARATH
ID ABIL2_ARATH Reviewed; 312 AA.
AC Q9M3A3; Q8GXQ1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein ABIL2;
DE AltName: Full=Abl interactor-like protein 2;
DE Short=AtABIL2;
GN Name=ABIL2; OrderedLocusNames=At3g49290; ORFNames=F2K15.150;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15659634; DOI=10.1105/tpc.104.027987;
RA Basu D., Le J., El-Din El-Assal S., Huang S., Zhang C., Mallery E.L.,
RA Koliantz G., Staiger C.J., Szymanski D.B.;
RT "DISTORTED3/SCAR2 is a putative Arabidopsis WAVE complex subunit that
RT activates the Arp2/3 complex and is required for epidermal morphogenesis.";
RL Plant Cell 17:502-524(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- FUNCTION: Involved in regulation of actin and microtubule organization.
CC Part of a WAVE complex that activates the Arp2/3 complex (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds SCAR. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9M3A3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9M3A3-2; Sequence=VSP_031020, VSP_031021;
CC -!- SIMILARITY: Belongs to the ABI family. {ECO:0000305}.
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DR EMBL; AY817013; AAW49257.1; -; mRNA.
DR EMBL; AL132956; CAB66408.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78522.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78523.1; -; Genomic_DNA.
DR EMBL; AK118112; BAC42738.1; -; mRNA.
DR PIR; T45834; T45834.
DR RefSeq; NP_001030832.1; NM_001035755.2. [Q9M3A3-1]
DR RefSeq; NP_190498.1; NM_114788.4. [Q9M3A3-1]
DR AlphaFoldDB; Q9M3A3; -.
DR SMR; Q9M3A3; -.
DR BioGRID; 9408; 2.
DR IntAct; Q9M3A3; 9.
DR STRING; 3702.AT3G49290.1; -.
DR iPTMnet; Q9M3A3; -.
DR PaxDb; Q9M3A3; -.
DR PRIDE; Q9M3A3; -.
DR ProteomicsDB; 244606; -. [Q9M3A3-1]
DR EnsemblPlants; AT3G49290.1; AT3G49290.1; AT3G49290. [Q9M3A3-1]
DR EnsemblPlants; AT3G49290.2; AT3G49290.2; AT3G49290. [Q9M3A3-1]
DR GeneID; 824090; -.
DR Gramene; AT3G49290.1; AT3G49290.1; AT3G49290. [Q9M3A3-1]
DR Gramene; AT3G49290.2; AT3G49290.2; AT3G49290. [Q9M3A3-1]
DR KEGG; ath:AT3G49290; -.
DR Araport; AT3G49290; -.
DR TAIR; locus:2082941; AT3G49290.
DR eggNOG; ENOG502R3IQ; Eukaryota.
DR HOGENOM; CLU_054853_1_0_1; -.
DR InParanoid; Q9M3A3; -.
DR OMA; NLRMSCI; -.
DR PhylomeDB; Q9M3A3; -.
DR PRO; PR:Q9M3A3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M3A3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR InterPro; IPR028457; ABI.
DR PANTHER; PTHR10460; PTHR10460; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..312
FT /note="Protein ABIL2"
FT /id="PRO_0000191795"
FT REGION 173..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..132
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074"
FT /id="VSP_031020"
FT VAR_SEQ 133..137
FT /note="RYILP -> MQSLS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074"
FT /id="VSP_031021"
SQ SEQUENCE 312 AA; 35777 MW; 6CA00ACDD755888B CRC64;
MPASHEASNY DEVSMQQSML FSDGLQDLKN LRAQLYSAAE YFELSYTTDD KKQIVVETLK
DYAVKALVNT VDHLGSVTYK VNDFIDEKVD EVSETELRVS CIEQRLRMCQ EYMDHEGRSQ
QSLVIDTPKF HKRYILPAGE IMTATNLEKL KYFGSSLEDA DDWNQFRNAV RATIRETPPP
PVRKSTSQSS SPRQPPQRSA TFSFTSTIPK KEQDKRSVSP HRFPLLRSGS VATRKSASIS
RPTTPSKSRS ITPIRYPSEP RRSASVRVAF EKDNQKETEQ QQPSKSKRLL KALLSRRKTK
KDDTLYTFLD EY
