SUCH1_CAEEL
ID SUCH1_CAEEL Reviewed; 798 AA.
AC Q95Q00;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Suppressor of spindle checkpoint defect 1 {ECO:0000312|WormBase:Y66D12A.17};
GN Name=such-1 {ECO:0000312|WormBase:Y66D12A.17};
GN Synonyms=som-2 {ECO:0000312|WormBase:Y66D12A.17};
GN ORFNames=Y66D12A.17 {ECO:0000312|WormBase:Y66D12A.17};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF GLY-27.
RX PubMed=17237515; DOI=10.1534/genetics.106.067918;
RA Tarailo M., Kitagawa R., Rose A.M.;
RT "Suppressors of spindle checkpoint defect (such) mutants identify new mdf-
RT 1/MAD1 interactors in Caenorhabditis elegans.";
RL Genetics 175:1665-1679(2007).
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=20944014; DOI=10.1534/genetics.110.123133;
RA Bezler A., Gonczy P.;
RT "Mutual antagonism between the anaphase promoting complex and the spindle
RT assembly checkpoint contributes to mitotic timing in Caenorhabditis
RT elegans.";
RL Genetics 186:1271-1283(2010).
RN [4] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE,
RP AND MUTAGENESIS OF GLU-693.
RX PubMed=20944012; DOI=10.1534/genetics.110.123463;
RA Stein K.K., Nesmith J.E., Ross B.D., Golden A.;
RT "Functional redundancy of paralogs of an anaphase promoting
RT complex/cyclosome subunit in Caenorhabditis elegans meiosis.";
RL Genetics 186:1285-1293(2010).
CC -!- FUNCTION: Probable component of the anaphase promoting
CC complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle (By similarity). The APC/C complex acts by mediating
CC ubiquitination and subsequent degradation of target proteins (By
CC similarity). Required for the metaphase to anaphase transition in
CC meiosis (PubMed:17237515, PubMed:20944012). Plays a role in the
CC segregation of DNA and centrioles during meiosis in male germ cells
CC (PubMed:20944014). {ECO:0000250|UniProtKB:Q9UJX4,
CC ECO:0000269|PubMed:17237515, ECO:0000269|PubMed:20944012,
CC ECO:0000269|PubMed:20944014}.
CC -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC -!- SUBUNIT: The APC/C complex is probably composed of at least 12
CC subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1,
CC mat-2, mat-3, such-1 and gfi-3. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in head neurons, vulval precursor cells
CC and in mature sperm stored in the spermatheca.
CC {ECO:0000269|PubMed:20944012}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing germ line and
CC throughout embryogenesis. {ECO:0000269|PubMed:20944012}.
CC -!- DISRUPTION PHENOTYPE: Double RNAi-mediated knockdown and/or mutagenesis
CC with gfi-3 results in increased embryonic lethality and the production
CC of one-cell arrested embryos. {ECO:0000269|PubMed:20944012}.
CC -!- SIMILARITY: Belongs to the APC5 family. {ECO:0000305}.
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DR EMBL; AL161712; CAC70137.2; -; Genomic_DNA.
DR RefSeq; NP_499485.2; NM_067084.5.
DR AlphaFoldDB; Q95Q00; -.
DR ComplexPortal; CPX-3382; Anaphase Promoting Complex/Cyclosome.
DR STRING; 6239.Y66D12A.17; -.
DR EPD; Q95Q00; -.
DR PaxDb; Q95Q00; -.
DR PeptideAtlas; Q95Q00; -.
DR EnsemblMetazoa; Y66D12A.17.1; Y66D12A.17.1; WBGene00013443.
DR GeneID; 176583; -.
DR KEGG; cel:CELE_Y66D12A.17; -.
DR UCSC; Y66D12A.17; c. elegans.
DR CTD; 176583; -.
DR WormBase; Y66D12A.17; CE41524; WBGene00013443; such-1.
DR eggNOG; ENOG502S8D6; Eukaryota.
DR GeneTree; ENSGT00390000018674; -.
DR HOGENOM; CLU_351691_0_0_1; -.
DR InParanoid; Q95Q00; -.
DR OMA; MCNRIAN; -.
DR OrthoDB; 477915at2759; -.
DR PhylomeDB; Q95Q00; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q95Q00; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00013443; Expressed in germ line (C elegans) and 3 other tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; IC:ComplexPortal.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IC:ComplexPortal.
DR GO; GO:1904666; P:regulation of ubiquitin protein ligase activity; IC:ComplexPortal.
DR InterPro; IPR037679; Apc5.
DR PANTHER; PTHR12830; PTHR12830; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Coiled coil; Developmental protein; Meiosis;
KW Mitosis; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..798
FT /note="Suppressor of spindle checkpoint defect 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000435336"
FT COILED 339..359
FT /evidence="ECO:0000255"
FT MUTAGEN 27
FT /note="G->D: In h1960; results in decreased brood size and
FT a high incidence of males (Him) phenotype."
FT /evidence="ECO:0000269|PubMed:17237515"
FT MUTAGEN 693
FT /note="E->K: In av9gf; gain of function mutation."
FT /evidence="ECO:0000269|PubMed:20944012"
SQ SEQUENCE 798 AA; 90911 MW; B12AAF2D9E53A577 CRC64;
MPPKKAQTRR IVSLDSLFGH TLLNITGEPV TPTKIAIFQL IRTLFHAHFG VGAVPSLKPF
DKDEKTRVFT VLYGLIIMKS EISYDDFRCI VRILNDGLGR SIYYRFVTSM EKLAHGEDQI
EMLFEDAFYT AKRPNHEKVL KREDSWLDEL TFMNSNSFLY IWIKRVMMQY TRTSQNGTFE
IAEKFQKWII SGTLEIISHP ILSGINRALP TEIDCSIRAR HWCAAQLRLV QLCPTKAMSY
FQILDWCDTI HRRHHDVVDV HLLRAAIFVQ LKNSSDAVKS LKQFFDMSML EITENSKHAL
ETLKLMSPSQ VALRFGPILQ GRVHRIFGER QIASALFAES IQQSQVNVDD MCNRIANMEV
TINSIYMSGP LLQRLSGETF AAGKKEEESV ENERRVQQNS VHAAVDLNVP TLRSLQKNFR
EDYELHAFLV SMCKFLLCIQ DMMDGKFFKH NSTADYVSVG FHRLRLLLDM NNKGFVLQAF
ANAIMTSGLI QSGMYHQAKR VAETMIVSNC DAPNSPILET ESHAVAGVNL VYSLAAVGDY
EKAQKTIDIL KNRFPENINW MAARHVDICS KIVNFERNFL LNKYSECSRH LAGLETSAPL
EFVLRKSLLL AATGKLAEAV LLLGTYECGD VRGSMRIHMQ MATIHTAYGQ FETAEIQIQE
AGKVAVNAHF LDANLLVVRR VGSLMLGRFM AREAYQVLHA LSAKIEHFGS FIEKAIYHVS
MARCLRLMHK DPRVHLKQCK AQIIGNKWPA MEKLLLTELT ILHHSGGLYP DEQKEMKAKE
RFGKIEADFP GPCTWMFI
