SUCO_RAT
ID SUCO_RAT Reviewed; 1253 AA.
AC Q710E6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=SUN domain-containing ossification factor;
DE AltName: Full=Membrane protein CH1;
DE AltName: Full=Protein osteopotentia homolog;
DE AltName: Full=SUN-like protein 1;
DE Flags: Precursor;
GN Name=Suco; Synonyms=Dd25, Opt;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Brain;
RA Verlaet M., Lakaye B., Grisar T.;
RT "Expression of mRNA encoding C1orf9 in brain structures of Rat.";
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for bone modeling during late embryogenesis.
CC Regulates type I collagen synthesis in osteoblasts during their
CC postnatal maturation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Rough endoplasmic reticulum membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC -!- PTM: O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by
CC POMGNT1. {ECO:0000250|UniProtKB:Q9UBS9}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8C341}.
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DR EMBL; AJ421447; CAD13342.1; -; mRNA.
DR RefSeq; NP_955435.1; NM_199403.1.
DR AlphaFoldDB; Q710E6; -.
DR SMR; Q710E6; -.
DR STRING; 10116.ENSRNOP00000068027; -.
DR GlyGen; Q710E6; 4 sites.
DR iPTMnet; Q710E6; -.
DR PhosphoSitePlus; Q710E6; -.
DR PaxDb; Q710E6; -.
DR PRIDE; Q710E6; -.
DR GeneID; 360863; -.
DR KEGG; rno:360863; -.
DR UCSC; RGD:735185; rat.
DR CTD; 51430; -.
DR RGD; 735185; Suco.
DR eggNOG; KOG1396; Eukaryota.
DR InParanoid; Q710E6; -.
DR OrthoDB; 890782at2759; -.
DR PhylomeDB; Q710E6; -.
DR PRO; PR:Q710E6; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0005791; C:rough endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:UniProtKB.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:0046850; P:regulation of bone remodeling; ISS:UniProtKB.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR045120; Suco/Slp1-like.
DR InterPro; IPR012919; SUN_dom.
DR PANTHER; PTHR12953; PTHR12953; 1.
DR Pfam; PF07738; Sad1_UNC; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51469; SUN; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Developmental protein; Endoplasmic reticulum; Glycoprotein;
KW Membrane; Osteogenesis; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1253
FT /note="SUN domain-containing ossification factor"
FT /id="PRO_0000302719"
FT TRANSMEM 1012..1032
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 284..453
FT /note="SUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00802"
FT REGION 112..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 910..1010
FT /evidence="ECO:0000255"
FT COMPBIAS 115..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1082
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UBS9"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 929
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 956
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1253 AA; 139260 MW; 4E21F2371612F8E1 CRC64;
MKKYRRALAL VSCLSLCSLV WLPSWHVCCK ESSSASTSYY SQDDNCAVGS EDIQFQKKNE
REEPSNAKVS EKSNSYLTIS PEENKLKDDY TVDECKIWKQ SKLSLPVVEA LPTVDSHEES
SSVVVGSENI ENSSSSSTSE TSPISKLDEI ENSGTLSVAK PGDTEQPEAD CDAGEAADAD
ASVEQPAFVS APESLVGQHI ENVSSSHGKE KVTKSEFESK VSVSEQDGGD PKSALNASDT
LKNESSDYTK PRETDPTSVT SPKDPEDIPT FDEWKKKVME VEKEKSQSLH PSSNGGPHAT
KKVQKNRNNY ASVECGAKIL AANPEAKSTS AILIENMDLY MLNPCSTKIW FVIELCEPIQ
VKQFDIANYE LFSSTPKDFL VSISDRYPTN KWIKLGTFHG RDERTVQSFP LDEQMYAKYV
KMFIKYIKVE LLSHFGSEHF CPLSLIRVFG TSMVEEYEEI ADSQYQSERQ ELFDEDYDYP
LDYNTVEDKS SKNLLGSATN AILNMVNIAA NILGAKTEDL TEGDKSISEN ATATTEPKMP
ESTGVSTPVP SPEYIIKEVH THDTEPPTSD PPKESPIVQL VQEEEEEASP STVTLLGSGE
QEDESSSWFE SETQILCSEL TSICCISSFS EYLYKWCSVR IALYRQHSRT VSKGKDVSPQ
PSLLPPVDSV EVSVLQPPSG NVDKEDMERE LETVALDDLS SVHQAHVRNH TVDTVELEPS
YPQTLSQSLP LDVTPEMDSL STVEGSESVK SEGGHKPSQV MPQESSVEFD DETEKKPESF
SSVAKLSVIY ETSKVNEVMD GPVKEDIVST HVVTKFPETK FPETVAPPPI NTAAVPESEG
METKPSLADT LKHVVTPVTD PSLPEVKEDE QSPDDALLRG LQRTATDFYA ELQNSTDLGY
GNGNLVHGSN QKESVFMRLN NRIKALEVNM SLSGRYLEEL SQRYRKQMEE MQKAFNKTIV
KLQNTSRIAE EQDQRQTEAI HLLQAQLTNM TQIVSNLSAT VAELKREVSD RQSYLVMSLV
LCVVLGLMLC MQRCRNTSQF DGDYTSKLPK SNQYPSPKRC FSSYDDMNLK RRTSFPLIRS
KSLQFTGKED PNDLYIVEPL KFSPEKKKKR CKYKTEKIET IKPADPLHPI ANGDIKGRKP
FTNQRDFSSM GEVYHSSYKG PPSEGSSETS SQSEESYFCG ISACTSLCNG QTQKTKLRRG
LKRRRSKVQD QGKLIKALIQ TKSGSLPSLH DIIKGNKEIT VGAFGVTAVS GHI
