SUCR1_MOUSE
ID SUCR1_MOUSE Reviewed; 317 AA.
AC Q99MT6; Q4V9V9;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Succinate receptor 1;
DE AltName: Full=G-protein coupled receptor 91;
GN Name=Sucnr1; Synonyms=Gpr91;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=11273702; DOI=10.1006/jmbi.2001.4520;
RA Wittenberger T., Schaller H.C., Hellebrand S.;
RT "An expressed sequence tag (EST) data mining strategy succeeding in the
RT discovery of new G-protein coupled receptors.";
RL J. Mol. Biol. 307:799-813(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=BALB/cJ;
RX PubMed=15141213; DOI=10.1038/nature02488;
RA He W., Miao F.J.-P., Lin D.C.-H., Schwandner R.T., Wang Z., Gao J.,
RA Chen J.-L., Tian H., Ling L.;
RT "Citric acid cycle intermediates as ligands for orphan G-protein-coupled
RT receptors.";
RL Nature 429:188-193(2004).
CC -!- FUNCTION: Receptor for succinate. {ECO:0000269|PubMed:15141213}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the kidney (proximal and
CC distal tubules and the juxtaglomerular apparatus). Weakly expressed in
CC liver, spleen and small intestine. {ECO:0000269|PubMed:11273702,
CC ECO:0000269|PubMed:15141213}.
CC -!- DISRUPTION PHENOTYPE: Abolition of succinate-induced hypertension.
CC {ECO:0000269|PubMed:15141213}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF295367; AAK01867.1; -; mRNA.
DR EMBL; BC096665; AAH96665.1; -; mRNA.
DR CCDS; CCDS38442.1; -.
DR RefSeq; NP_115776.2; NM_032400.2.
DR AlphaFoldDB; Q99MT6; -.
DR SMR; Q99MT6; -.
DR STRING; 10090.ENSMUSP00000029326; -.
DR ChEMBL; CHEMBL4739861; -.
DR GlyGen; Q99MT6; 1 site.
DR iPTMnet; Q99MT6; -.
DR PhosphoSitePlus; Q99MT6; -.
DR PaxDb; Q99MT6; -.
DR PRIDE; Q99MT6; -.
DR ProteomicsDB; 257373; -.
DR Antibodypedia; 18315; 266 antibodies from 28 providers.
DR DNASU; 84112; -.
DR Ensembl; ENSMUST00000029326; ENSMUSP00000029326; ENSMUSG00000027762.
DR GeneID; 84112; -.
DR KEGG; mmu:84112; -.
DR UCSC; uc008pja.2; mouse.
DR CTD; 56670; -.
DR MGI; MGI:1934135; Sucnr1.
DR VEuPathDB; HostDB:ENSMUSG00000027762; -.
DR eggNOG; ENOG502QVWP; Eukaryota.
DR GeneTree; ENSGT01030000234621; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q99MT6; -.
DR OMA; VMCFFYY; -.
DR OrthoDB; 1133445at2759; -.
DR PhylomeDB; Q99MT6; -.
DR TreeFam; TF350009; -.
DR Reactome; R-MMU-373076; Class A/1 (Rhodopsin-like receptors).
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 84112; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q99MT6; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q99MT6; protein.
DR Bgee; ENSMUSG00000027762; Expressed in white adipose tissue and 49 other tissues.
DR Genevisible; Q99MT6; MM.
DR GO; GO:0009986; C:cell surface; TAS:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
DR GO; GO:0002281; P:macrophage activation involved in immune response; IMP:MGI.
DR GO; GO:0050921; P:positive regulation of chemotaxis; IMP:MGI.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IMP:MGI.
DR GO; GO:0060177; P:regulation of angiotensin metabolic process; IMP:MGI.
DR GO; GO:0002001; P:renin secretion into blood stream; IMP:MGI.
DR GO; GO:0051592; P:response to calcium ion; IMP:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..317
FT /note="Succinate receptor 1"
FT /id="PRO_0000070135"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..246
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 91..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 106
FT /note="I -> M (in Ref. 1; AAK01867)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="F -> L (in Ref. 1; AAK01867)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="F -> V (in Ref. 1; AAK01867)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 36765 MW; 378C0738E108B3A5 CRC64;
MAQNLSCENW LATEAILNKY YLSAFYAIEF IFGLLGNVTV VFGYLFCMKN WNSSNVYLFN
LSISDFAFLC TLPILIKSYA NDKGTYGDVL CISNRYVLHT NLYTSILFLT FISMDRYLLM
KYPFREHFLQ KKEFAILISL AVWALVTLEV LPMLTFINSV PKEEGSNCID YASSGNPEHN
LIYSLCLTLL GFLIPLSVMC FFYYKMVVFL KRRSQQQATA LPLDKPQRLV VLAVVIFSIL
FTPYHIMRNL RIASRLDSWP QGCTQKAIKS IYTLTRPLAF LNSAINPIFY FLMGDHYREM
LISKFRQYFK SLTSFRT
