SUFE2_ARATH
ID SUFE2_ARATH Reviewed; 258 AA.
AC Q9FXE3;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=SufE-like protein 2, chloroplastic;
DE AltName: Full=Protein SULFUR E 2;
GN Name=SUFE2; OrderedLocusNames=At1g67810; ORFNames=F12A21.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17452319; DOI=10.1074/jbc.m701428200;
RA Narayana Murthy U.M., Ollagnier-de-Choudens S., Sanakis Y.,
RA Abdel-Ghany S.E., Rousset C., Ye H., Fontecave M., Pilon-Smits E.A.,
RA Pilon M.;
RT "Characterization of Arabidopsis thaliana SufE2 and SufE3: functions in
RT chloroplast iron-sulfur cluster assembly and Nad synthesis.";
RL J. Biol. Chem. 282:18254-18264(2007).
CC -!- FUNCTION: Participates in cysteine desulfurization mediated by NFS2.
CC Can activate the cysteine desulfurase activity of NFS2 in vitro.
CC Cysteine desulfurization mobilizes sulfur from L-cysteine to yield L-
CC alanine and supplies the inorganic sulfur for iron-sulfur (Fe-S)
CC cluster formation. {ECO:0000269|PubMed:17452319}.
CC -!- PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:17452319}.
CC -!- TISSUE SPECIFICITY: Highly expressed in flowers and pollen, and at low
CC levels in roots, leaves and stems. {ECO:0000269|PubMed:17452319}.
CC -!- SIMILARITY: Belongs to the SufE family. {ECO:0000305}.
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DR EMBL; AC008113; AAG28910.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34701.1; -; Genomic_DNA.
DR EMBL; BT029461; ABK59690.1; -; mRNA.
DR RefSeq; NP_176947.1; NM_105449.4.
DR AlphaFoldDB; Q9FXE3; -.
DR SMR; Q9FXE3; -.
DR STRING; 3702.AT1G67810.1; -.
DR PaxDb; Q9FXE3; -.
DR PRIDE; Q9FXE3; -.
DR ProteomicsDB; 228281; -.
DR EnsemblPlants; AT1G67810.1; AT1G67810.1; AT1G67810.
DR GeneID; 843107; -.
DR Gramene; AT1G67810.1; AT1G67810.1; AT1G67810.
DR KEGG; ath:AT1G67810; -.
DR Araport; AT1G67810; -.
DR TAIR; locus:2824065; AT1G67810.
DR eggNOG; ENOG502S1HZ; Eukaryota.
DR HOGENOM; CLU_077250_0_0_1; -.
DR InParanoid; Q9FXE3; -.
DR OMA; EIKMDEF; -.
DR OrthoDB; 1339417at2759; -.
DR PhylomeDB; Q9FXE3; -.
DR UniPathway; UPA00266; -.
DR PRO; PR:Q9FXE3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FXE3; baseline and differential.
DR Genevisible; Q9FXE3; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0008047; F:enzyme activator activity; IDA:TAIR.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IC:TAIR.
DR GO; GO:0051176; P:positive regulation of sulfur metabolic process; IDA:TAIR.
DR InterPro; IPR003808; Fe-S_metab-assoc_dom.
DR PANTHER; PTHR43597; PTHR43597; 1.
DR Pfam; PF02657; SufE; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Plastid; Reference proteome.
FT CHAIN 1..258
FT /note="SufE-like protein 2, chloroplastic"
FT /id="PRO_0000423487"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 122
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 258 AA; 28968 MW; DB7B34624037421B CRC64;
MNTSSSFKAL ASPPLISTSR PTTKSFPNPR FTSRFSPKPI TCMRDSLNLG SNPKAPSPFS
LATVSVDAPL GTKTSDKLRI LVSEFRSLTE PIDRVKRLLN YAATLAPLDE SARISENRVT
GCTTQVWLEI KMDEFGRMRF KADSDSEISK GFCSCLIWIL DGAKPEEVMG VRSEDLSEMN
VGVHGKEQSR VNTWHNVLMS MQKRTMTLVA TDVAHQRGQR PPHQHDLLFK YVNGSYMESS
KVHDYSISLL PLYYDFII
