SUFE_SALDC
ID SUFE_SALDC Reviewed; 138 AA.
AC B5FIM2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Cysteine desulfuration protein SufE {ECO:0000255|HAMAP-Rule:MF_01832};
GN Name=sufE {ECO:0000255|HAMAP-Rule:MF_01832}; OrderedLocusNames=SeD_A1968;
OS Salmonella dublin (strain CT_02021853).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=439851;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT_02021853;
RX PubMed=21602358; DOI=10.1128/jb.00297-11;
RA Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA Leclerc J.E., Ravel J., Cebula T.A.;
RT "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT CRISPR-mediated adaptive sublineage evolution.";
RL J. Bacteriol. 193:3556-3568(2011).
CC -!- FUNCTION: Participates in cysteine desulfuration mediated by SufS.
CC Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-
CC alanine and constitutes an essential step in sulfur metabolism for
CC biosynthesis of a variety of sulfur-containing biomolecules. Functions
CC as a sulfur acceptor for SufS, by mediating the direct transfer of the
CC sulfur atom from the S-sulfanylcysteine of SufS, an intermediate
CC product of cysteine desulfuration process. {ECO:0000255|HAMAP-
CC Rule:MF_01832}.
CC -!- PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_01832}.
CC -!- SUBUNIT: Homodimer. Interacts with SufS. {ECO:0000255|HAMAP-
CC Rule:MF_01832}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01832}.
CC -!- SIMILARITY: Belongs to the SufE family. {ECO:0000255|HAMAP-
CC Rule:MF_01832}.
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DR EMBL; CP001144; ACH74785.1; -; Genomic_DNA.
DR RefSeq; WP_000729468.1; NC_011205.1.
DR AlphaFoldDB; B5FIM2; -.
DR SMR; B5FIM2; -.
DR KEGG; sed:SeD_A1968; -.
DR HOGENOM; CLU_124502_1_1_6; -.
DR OMA; DWMQRYE; -.
DR UniPathway; UPA00266; -.
DR Proteomes; UP000008322; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR HAMAP; MF_01832; SufE; 1.
DR InterPro; IPR023939; Cysteine_desulfuration_SufE.
DR InterPro; IPR003808; Fe-S_metab-assoc_dom.
DR PANTHER; PTHR43597; PTHR43597; 1.
DR Pfam; PF02657; SufE; 1.
PE 3: Inferred from homology;
KW Cytoplasm.
FT CHAIN 1..138
FT /note="Cysteine desulfuration protein SufE"
FT /id="PRO_1000188331"
FT ACT_SITE 51
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01832"
SQ SEQUENCE 138 AA; 15760 MW; E284BEC1E1682DFB CRC64;
MAALPDKEKL LRNFTRCANW EEKYLYIIEL GQRLAELNPQ DRNPQNTIHG CQSQVWIVMR
RNANGIIELQ GDSDAAIVKG LMAVVFILYH QMTAQDIVHF DVRPWFEKMA LAQHLTPSRS
QGLEAMIRAI RAKAATLS