ID   SUFE_SALTY              Reviewed;         138 AA.
AC   Q8ZPQ1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Cysteine desulfuration protein SufE {ECO:0000255|HAMAP-Rule:MF_01832};
GN   Name=sufE {ECO:0000255|HAMAP-Rule:MF_01832}; OrderedLocusNames=STM1374;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Participates in cysteine desulfuration mediated by SufS.
CC       Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-
CC       alanine and constitutes an essential step in sulfur metabolism for
CC       biosynthesis of a variety of sulfur-containing biomolecules. Functions
CC       as a sulfur acceptor for SufS, by mediating the direct transfer of the
CC       sulfur atom from the S-sulfanylcysteine of SufS, an intermediate
CC       product of cysteine desulfuration process. {ECO:0000255|HAMAP-
CC       Rule:MF_01832}.
CC   -!- PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01832}.
CC   -!- SUBUNIT: Homodimer. Interacts with SufS. {ECO:0000255|HAMAP-
CC       Rule:MF_01832}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01832}.
CC   -!- SIMILARITY: Belongs to the SufE family. {ECO:0000255|HAMAP-
CC       Rule:MF_01832}.
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DR   EMBL; AE006468; AAL20298.1; -; Genomic_DNA.
DR   RefSeq; NP_460339.1; NC_003197.2.
DR   RefSeq; WP_000729468.1; NC_003197.2.
DR   PDB; 3G0M; X-ray; 1.76 A; A=1-138.
DR   PDBsum; 3G0M; -.
DR   AlphaFoldDB; Q8ZPQ1; -.
DR   SMR; Q8ZPQ1; -.
DR   STRING; 99287.STM1374; -.
DR   PaxDb; Q8ZPQ1; -.
DR   EnsemblBacteria; AAL20298; AAL20298; STM1374.
DR   GeneID; 1252892; -.
DR   KEGG; stm:STM1374; -.
DR   PATRIC; fig|99287.12.peg.1457; -.
DR   HOGENOM; CLU_124502_1_1_6; -.
DR   OMA; DWMQRYE; -.
DR   PhylomeDB; Q8ZPQ1; -.
DR   BioCyc; SENT99287:STM1374-MON; -.
DR   UniPathway; UPA00266; -.
DR   EvolutionaryTrace; Q8ZPQ1; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   HAMAP; MF_01832; SufE; 1.
DR   InterPro; IPR023939; Cysteine_desulfuration_SufE.
DR   InterPro; IPR003808; Fe-S_metab-assoc_dom.
DR   PANTHER; PTHR43597; PTHR43597; 1.
DR   Pfam; PF02657; SufE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Reference proteome.
FT   CHAIN           1..138
FT                   /note="Cysteine desulfuration protein SufE"
FT                   /id="PRO_0000202131"
FT   ACT_SITE        51
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01832"
FT   HELIX           7..15
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           20..32
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           39..41
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           44..46
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   STRAND          50..53
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   STRAND          55..61
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   STRAND          65..75
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           76..89
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           94..99
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           103..109
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           112..114
FT                   /evidence="ECO:0007829|PDB:3G0M"
FT   HELIX           117..135
FT                   /evidence="ECO:0007829|PDB:3G0M"
SQ   SEQUENCE   138 AA;  15760 MW;  E284BEC1E1682DFB CRC64;
     MAALPDKEKL LRNFTRCANW EEKYLYIIEL GQRLAELNPQ DRNPQNTIHG CQSQVWIVMR
     RNANGIIELQ GDSDAAIVKG LMAVVFILYH QMTAQDIVHF DVRPWFEKMA LAQHLTPSRS
     QGLEAMIRAI RAKAATLS