SUFE_YERE8
ID SUFE_YERE8 Reviewed; 140 AA.
AC A1JPC1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Cysteine desulfuration protein SufE {ECO:0000255|HAMAP-Rule:MF_01832};
GN Name=sufE {ECO:0000255|HAMAP-Rule:MF_01832}; OrderedLocusNames=YE2167;
OS Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS 8081).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=393305;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13174 / 8081;
RX PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA Prentice M.B.;
RT "The complete genome sequence and comparative genome analysis of the high
RT pathogenicity Yersinia enterocolitica strain 8081.";
RL PLoS Genet. 2:2039-2051(2006).
CC -!- FUNCTION: Participates in cysteine desulfuration mediated by SufS.
CC Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-
CC alanine and constitutes an essential step in sulfur metabolism for
CC biosynthesis of a variety of sulfur-containing biomolecules. Functions
CC as a sulfur acceptor for SufS, by mediating the direct transfer of the
CC sulfur atom from the S-sulfanylcysteine of SufS, an intermediate
CC product of cysteine desulfuration process. {ECO:0000255|HAMAP-
CC Rule:MF_01832}.
CC -!- PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_01832}.
CC -!- SUBUNIT: Homodimer. Interacts with SufS. {ECO:0000255|HAMAP-
CC Rule:MF_01832}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01832}.
CC -!- SIMILARITY: Belongs to the SufE family. {ECO:0000255|HAMAP-
CC Rule:MF_01832}.
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DR EMBL; AM286415; CAL12237.1; -; Genomic_DNA.
DR RefSeq; WP_011816383.1; NC_008800.1.
DR RefSeq; YP_001006407.1; NC_008800.1.
DR AlphaFoldDB; A1JPC1; -.
DR SMR; A1JPC1; -.
DR STRING; 393305.YE2167; -.
DR EnsemblBacteria; CAL12237; CAL12237; YE2167.
DR KEGG; yen:YE2167; -.
DR PATRIC; fig|393305.7.peg.2332; -.
DR eggNOG; COG2166; Bacteria.
DR HOGENOM; CLU_124502_1_1_6; -.
DR OMA; DWMQRYE; -.
DR UniPathway; UPA00266; -.
DR Proteomes; UP000000642; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR HAMAP; MF_01832; SufE; 1.
DR InterPro; IPR023939; Cysteine_desulfuration_SufE.
DR InterPro; IPR003808; Fe-S_metab-assoc_dom.
DR PANTHER; PTHR43597; PTHR43597; 1.
DR Pfam; PF02657; SufE; 1.
PE 3: Inferred from homology;
KW Cytoplasm.
FT CHAIN 1..140
FT /note="Cysteine desulfuration protein SufE"
FT /id="PRO_1000070451"
FT ACT_SITE 51
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01832"
SQ SEQUENCE 140 AA; 15414 MW; 6C566E0A1CC2F37B CRC64;
MAGLPDKDKL IRNFSRCLNW EEKYLYVIEL GAQLPPLTEQ QRQPDNLISG CQSQVWIAMS
TSTEGQVVFA GDSDAAIVKG LVVVVFILYQ GLTPQQIIDL DVRPFFADLA LSQHLTPSRS
QGLEAMIRAI RAKAAVLKAG