SUGB_MYCTU
ID SUGB_MYCTU Reviewed; 274 AA.
AC P9WG01; F2GFS5; L0T918; O50453; Q7D8J7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Trehalose transport system permease protein SugB;
GN Name=sugB; OrderedLocusNames=Rv1237;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP FUNCTION IN TREHALOSE IMPORT, AND SUBUNIT.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21118978; DOI=10.1073/pnas.1014642108;
RA Kalscheuer R., Weinrick B., Veeraraghavan U., Besra G.S., Jacobs W.R. Jr.;
RT "Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for
RT virulence of Mycobacterium tuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:21761-21766(2010).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Part of the ABC transporter complex LpqY-SugA-SugB-SugC,
CC which is highly specific for uptake of trehalose. Involved in the
CC recycling of extracellular trehalose released from trehalose-containing
CC molecules synthesized by M.tuberculosis. Trehalose uptake is essential
CC for virulence. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000269|PubMed:21118978}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (SugC),
CC two transmembrane proteins (Suga and SugB) and a solute-binding protein
CC (LpqY). {ECO:0000305|PubMed:21118978}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AL123456; CCP43993.1; -; Genomic_DNA.
DR PIR; D70952; D70952.
DR RefSeq; NP_215753.1; NC_000962.3.
DR RefSeq; WP_003900298.1; NZ_NVQJ01000039.1.
DR AlphaFoldDB; P9WG01; -.
DR SMR; P9WG01; -.
DR STRING; 83332.Rv1237; -.
DR PaxDb; P9WG01; -.
DR GeneID; 45425207; -.
DR GeneID; 887121; -.
DR KEGG; mtu:Rv1237; -.
DR PATRIC; fig|83332.111.peg.1382; -.
DR TubercuList; Rv1237; -.
DR eggNOG; COG0395; Bacteria.
DR OMA; IAFFIAW; -.
DR PhylomeDB; P9WG01; -.
DR BioCyc; MetaCyc:G185E-5408-MON; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..274
FT /note="Trehalose transport system permease protein SugB"
FT /id="PRO_0000419316"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 66..259
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 274 AA; 29158 MW; 772A9A53F559332C CRC64;
MGARRATYWA VLDTLVVGYA LLPVLWIFSL SLKPTSTVKD GKLIPSTVTF DNYRGIFRGD
LFSSALINSI GIGLITTVIA VVLGAMAAYA VARLEFPGKR LLIGAALLIT MFPSISLVTP
LFNIERAIGL FDTWPGLILP YITFALPLAI YTLSAFFREI PWDLEKAAKM DGATPGQAFR
KVIVPLAAPG LVTAAILVFI FAWNDLLLAL SLTATKAAIT APVAIANFTG SSQFEEPTGS
IAAGAIVITI PIIVFVLIFQ RRIVAGLTSG AVKG
