SUGP1_RAT
ID SUGP1_RAT Reviewed; 644 AA.
AC Q68FU8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=SURP and G-patch domain-containing protein 1;
DE AltName: Full=Splicing factor 4;
GN Name=Sugp1; Synonyms=Sf4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408 AND SER-410, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Plays a role in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Component of the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; BC079341; AAH79341.1; -; mRNA.
DR RefSeq; NP_001011920.1; NM_001011920.1.
DR AlphaFoldDB; Q68FU8; -.
DR SMR; Q68FU8; -.
DR STRING; 10116.ENSRNOP00000027826; -.
DR iPTMnet; Q68FU8; -.
DR PhosphoSitePlus; Q68FU8; -.
DR jPOST; Q68FU8; -.
DR PaxDb; Q68FU8; -.
DR PRIDE; Q68FU8; -.
DR Ensembl; ENSRNOT00000110921; ENSRNOP00000082578; ENSRNOG00000052111.
DR GeneID; 290666; -.
DR KEGG; rno:290666; -.
DR UCSC; RGD:1310496; rat.
DR CTD; 57794; -.
DR RGD; 1310496; Sugp1.
DR eggNOG; KOG0965; Eukaryota.
DR GeneTree; ENSGT00410000025695; -.
DR HOGENOM; CLU_028403_0_0_1; -.
DR InParanoid; Q68FU8; -.
DR OMA; QWLEIKI; -.
DR OrthoDB; 1232201at2759; -.
DR PhylomeDB; Q68FU8; -.
DR TreeFam; TF326321; -.
DR Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q68FU8; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000052111; Expressed in pancreas and 20 other tissues.
DR Genevisible; Q68FU8; RN.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.790; -; 2.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR040169; SUGP1/2.
DR InterPro; IPR000061; Surp.
DR InterPro; IPR035967; SWAP/Surp_sf.
DR PANTHER; PTHR23340; PTHR23340; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF01805; Surp; 2.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00648; SWAP; 2.
DR SUPFAM; SSF109905; SSF109905; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50128; SURP; 2.
PE 1: Evidence at protein level;
KW mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..644
FT /note="SURP and G-patch domain-containing protein 1"
FT /id="PRO_0000097703"
FT REPEAT 188..230
FT /note="SURP motif 1"
FT REPEAT 263..306
FT /note="SURP motif 2"
FT DOMAIN 561..608
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 44..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 379..385
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 382..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 128
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWZ8"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWZ8"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWZ8"
FT MOD_RES 408
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 410
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 413
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWZ8"
FT MOD_RES 484
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWZ8"
SQ SEQUENCE 644 AA; 72595 MW; DBA91AAE13E174F7 CRC64;
MSLKMDNRDV AGKANRWFGM AQPKSGKMNM NILHQEELIA QKKREIEARM EQKARQSHVA
SPQPPHPGEV ADAQNSCISN KFANDGSFLQ QFLKLQKAQA STDSAPRAPP SSPAPSSLKR
PLLLSKRTGL GLGSPMGPVK NYSHAKQLPV AHRPSVFQSP DDDDEEEDYE QWLEIKVSPP
EGAETRRVIE KLARFVAEGG PELEKVAMED YKDNPAFTFL HDKNSREFLY YRKKVAEIRK
EAQKPQAATQ KVSPPEDEEA KNLAEKLARF IADGGPEVET IALQNNRENQ AFSFLYDPNS
QGYRYYKQKL EEFRKAKAGS TGSLPAPVPN PSLRRKSAPE ALSGAVPPIT ACPTPVAPAP
AVNPTPSIPG KPTATATVKR KRKSRWGPEE DKVELPPAEL AQKDTDASPS PLSVQDLKGL
GYEKGKPVGL VGVTELSDAQ KKQLKEQQEM QQMYDMIMQH KRAMQDMQLL WEKALQQHQH
GYDSDEEVDS ELGTWEHQLR RMEMDKTREW AEQLTQMGRG KHFIGDFLPP DELEKFMETF
KALKEGREPD YSEYKEFKLT VENIGYQMLM KMGWKEGEGL GTEGQGIKNP VNKGATTIDG
AGFGIDRPAE LSKEDDEYEA FRKRMMLAYR FRPNPLNNPR RPYY
