SUGP2_MOUSE
ID SUGP2_MOUSE Reviewed; 1067 AA.
AC Q8CH09; Q6PG19; Q80UY8; Q8BY32; Q8CFM0;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=SURP and G-patch domain-containing protein 2;
DE AltName: Full=Arginine/serine-rich-splicing factor 14;
DE AltName: Full=Splicing factor, arginine/serine-rich 14;
GN Name=Sugp2; Synonyms=Sfrs14, Srsf14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12594045; DOI=10.1016/s0378-1119(02)01230-1;
RA Sampson N.D., Hewitt J.E.;
RT "SF4 and SFRS14, two related putative splicing factors on human chromosome
RT 19p13.11.";
RL Gene 305:91-100(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-666.
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Mammary gland, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206; SER-740; THR-744 AND
RP SER-838, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in mRNA splicing. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57305.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF518875; AAN77118.1; -; mRNA.
DR EMBL; AK042293; BAC31218.1; -; mRNA.
DR EMBL; BC023276; AAH23276.1; -; mRNA.
DR EMBL; BC042763; AAH42763.1; -; mRNA.
DR EMBL; BC057305; AAH57305.1; ALT_FRAME; mRNA.
DR CCDS; CCDS22362.1; -.
DR RefSeq; NP_001161762.1; NM_001168290.1.
DR RefSeq; NP_766343.3; NM_172755.3.
DR RefSeq; XP_006509707.1; XM_006509644.2.
DR RefSeq; XP_006509708.1; XM_006509645.3.
DR RefSeq; XP_006509709.1; XM_006509646.1.
DR AlphaFoldDB; Q8CH09; -.
DR SMR; Q8CH09; -.
DR BioGRID; 231520; 1.
DR IntAct; Q8CH09; 1.
DR MINT; Q8CH09; -.
DR STRING; 10090.ENSMUSP00000091167; -.
DR iPTMnet; Q8CH09; -.
DR PhosphoSitePlus; Q8CH09; -.
DR EPD; Q8CH09; -.
DR jPOST; Q8CH09; -.
DR MaxQB; Q8CH09; -.
DR PaxDb; Q8CH09; -.
DR PeptideAtlas; Q8CH09; -.
DR PRIDE; Q8CH09; -.
DR ProteomicsDB; 257375; -.
DR Antibodypedia; 28312; 159 antibodies from 26 providers.
DR DNASU; 234373; -.
DR Ensembl; ENSMUST00000093458; ENSMUSP00000091167; ENSMUSG00000036054.
DR Ensembl; ENSMUST00000131489; ENSMUSP00000114833; ENSMUSG00000036054.
DR Ensembl; ENSMUST00000164403; ENSMUSP00000128029; ENSMUSG00000036054.
DR GeneID; 234373; -.
DR KEGG; mmu:234373; -.
DR UCSC; uc009lzk.2; mouse.
DR CTD; 10147; -.
DR MGI; MGI:2678085; Sugp2.
DR VEuPathDB; HostDB:ENSMUSG00000036054; -.
DR eggNOG; KOG0965; Eukaryota.
DR GeneTree; ENSGT00410000025695; -.
DR HOGENOM; CLU_010012_0_0_1; -.
DR InParanoid; Q8CH09; -.
DR OMA; CPSIRFT; -.
DR OrthoDB; 1232201at2759; -.
DR PhylomeDB; Q8CH09; -.
DR TreeFam; TF326321; -.
DR BioGRID-ORCS; 234373; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Sugp2; mouse.
DR PRO; PR:Q8CH09; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8CH09; protein.
DR Bgee; ENSMUSG00000036054; Expressed in spermatocyte and 262 other tissues.
DR ExpressionAtlas; Q8CH09; baseline and differential.
DR Genevisible; Q8CH09; MM.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.790; -; 2.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR040169; SUGP1/2.
DR InterPro; IPR000061; Surp.
DR InterPro; IPR035967; SWAP/Surp_sf.
DR PANTHER; PTHR23340; PTHR23340; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF01805; Surp; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00648; SWAP; 2.
DR SUPFAM; SSF109905; SSF109905; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50128; SURP; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Ubl conjugation.
FT CHAIN 1..1067
FT /note="SURP and G-patch domain-containing protein 2"
FT /id="PRO_0000097709"
FT REPEAT 573..616
FT /note="SURP motif 1"
FT REPEAT 770..813
FT /note="SURP motif 2"
FT DOMAIN 996..1042
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 177..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 980..985
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 678..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..882
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IX01"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 265
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8IX01"
FT MOD_RES 267
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IX01"
FT MOD_RES 586
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IX01"
FT MOD_RES 740
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 744
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 838
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 219
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8IX01"
FT VARIANT 666
FT /note="I -> L (in strain: FVB/N)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT CONFLICT 923
FT /note="G -> A (in Ref. 1; AAN77118)"
FT /evidence="ECO:0000305"
FT CONFLICT 949
FT /note="P -> T (in Ref. 2; BAC31218)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1067 AA; 118103 MW; 8A191DC7C71C4949 CRC64;
MAARRMAQES LDSVLQEKSK RYGDSEAVGE ALHLKAQDLL RTGSRARADV YEDIHGDSRY
SASGSGVYSL DMGREGLRGD MFVGPSFRSS NQSVGEDSYL RKECGRDLEP AHTDSRDQSF
GHRNLGHFPS QDWKLALRGS WEQDLGHSVS QESSWSQEYG FGPSLLGDLA SSRRMEKESR
DYDLDHPGEV DSVSRSSGQV LTRGRSLNIA DQEGTLLGKG DTQGLLGAKG VGKLITLKSM
TTKKIPVASR ITSKPQGTNQ IQKPTPSPDV TIGTSPVLDE IQFAALKIPL GLDLRTLGLP
RRKMGFDAID KADVFSRFGI EIIKWAGFHT IKDDLKFSQL FQTLFELETE TCAKMLASFK
CSLKPEHRDF CFFTIKFLKH SALKTPRVDN EFLNMLLDKG AVKTKNCFFE IIKPFDKSIM
RLQDRLLKGV TPLLMACNAY ELSVKMKTLT SPLDLAMALE TTNSLCRKSL ALLGQTFSLA
SSFRQEKILE AVGLQDIAPS PAYFPNFEDS TLFGREYIDH LKAWLMASGY PLQLKRAVPP
ESREQKTTAQ TWASSTLSQA VPQRADHRVV DTIDQLVMRV IQGRLSPRER TLLLQDPAYW
FLSDESSLEY KYYKLKLAES QRLNHSWPIV ERRPTPAQCA VRAMLYAQAV RSLKRRLLPW
QRRRLIRSQG PRGLKAKKAT TAQQTSLSSG TRQKHHGRQA SGSLRVKPPP RDSSDAAQDC
LSEPAKPCPQ PSSPGALGPS PRPTGADDSE ALPASSRCPS ANMDAKTMET AEKLARFVAQ
VGPEIEQFSI ENSTDNPDLW FLHDQSSSAF KFYREKVLEL CPSISFQSTG EAGDSVQSPT
AGKEGKGEPQ EGHPEQEASL EGTEVLPEEE EEDEEESEDE GGEETSTLRP QAGAAKCPGS
EGSSPTDSIP GEGSREDQAS TPGLSQASSG SCFPRKRISS KSLKVGMIPA PKRVCLIQES
KVHEPVRIAY DRPRGRPIAK KKKPKDMEFS QQKLTDKNVG FQMLQKMGWK EGHGLGSLGK
GIREPVSVGA LSEGEGLGAD GPEQKEDTFD VFRQRMMQMY RHKRASK
