位置:首页 > 蛋白库 > SUHB_BUCBP
SUHB_BUCBP
ID   SUHB_BUCBP              Reviewed;         266 AA.
AC   Q89AK9;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Nus factor SuhB {ECO:0000250|UniProtKB:P0ADG4};
DE   AltName: Full=Inositol-1-monophosphatase;
DE            Short=I-1-Pase;
DE            Short=IMPase;
DE            Short=Inositol-1-phosphatase;
DE            EC=3.1.3.25 {ECO:0000250|UniProtKB:P0ADG4};
GN   Name=suhB; OrderedLocusNames=bbp_264;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: Part of the processive rRNA transcription and antitermination
CC       complex (rrnTAC). The complex forms an RNA-chaperone ring around the
CC       RNA exit tunnel of RNA polymerase (RNAP). It supports rapid
CC       transcription and antitermination of rRNA operons, cotranscriptional
CC       rRNA folding, and annealing of distal rRNA regions to allow correct
CC       ribosome biogenesis. This subunit may play a central role in organizing
CC       the structure. {ECO:0000250|UniProtKB:P0ADG4}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate;
CC         Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25;
CC         Evidence={ECO:0000250|UniProtKB:P0ADG4};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:P0ADG4};
CC   -!- SUBUNIT: Homodimer. The rRNA transcription and antitermination complex
CC       (rrnTAC) consists of RNA polymerase (RNAP), NusA, NusB, NusE (rpsJ),
CC       NusG, SubB, ribosomal protein S4, DNA and precursor rRNA; S4 is more
CC       flexible than other subunits. {ECO:0000250|UniProtKB:P0ADG4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0ADG4}.
CC   -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016826; AAO26990.1; -; Genomic_DNA.
DR   RefSeq; WP_011091391.1; NC_004545.1.
DR   AlphaFoldDB; Q89AK9; -.
DR   SMR; Q89AK9; -.
DR   STRING; 224915.bbp_264; -.
DR   EnsemblBacteria; AAO26990; AAO26990; bbp_264.
DR   GeneID; 56470806; -.
DR   KEGG; bab:bbp_264; -.
DR   eggNOG; COG0483; Bacteria.
DR   HOGENOM; CLU_044118_0_0_6; -.
DR   OMA; VHQELEF; -.
DR   OrthoDB; 1741160at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:InterPro.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   CDD; cd01639; IMPase; 1.
DR   InterPro; IPR033942; IMPase.
DR   InterPro; IPR000760; Inositol_monophosphatase-like.
DR   Pfam; PF00459; Inositol_P; 1.
DR   PRINTS; PR00377; IMPHPHTASES.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Hydrolase; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; Transcription; Transcription antitermination;
KW   Transcription regulation.
FT   CHAIN           1..266
FT                   /note="Nus factor SuhB"
FT                   /id="PRO_0000142557"
FT   BINDING         86..89
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   266 AA;  30496 MW;  4C4166EB634D556A CRC64;
     MHPILNIAIR VARKCGNILI QYYDRNKTNN EKQILKKDFI TKIIFVLEKT MIDMIHKSYP
     EHSIITYHKN NKIFKNTEII WLINALDGIK NFENNLPHFC ISIAIIVRKT TQISVIYDPI
     RNELFTSVKG QGSQLNGYRM RCKSTNTLKR SLVGLVYPCN NSKFQNYFFT IINLLFSHEV
     KLRCTGCISL DCAYVAMGRL DYLFNGNLIP LLFSSGSLQI KESGGLISDL NGGHDYVSSG
     IILIGNPKLM RVILVKIREL FQNNLK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024