SUHR_RHIME
ID SUHR_RHIME Reviewed; 633 AA.
AC P15715;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=RpoH suppressor;
GN Name=suhR; OrderedLocusNames=R02096; ORFNames=SMc01492;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-281.
RC STRAIN=1021;
RX PubMed=2113906; DOI=10.1128/jb.172.7.3559-3568.1990;
RA Bent A.F., Signer E.R.;
RT "Rhizobium meliloti suhR suppresses the phenotype of an Escherichia coli
RT RNA polymerase sigma 32 mutant.";
RL J. Bacteriol. 172:3559-3568(1990).
CC -!- FUNCTION: This protein is non-essential for R.meliloti growth, but
CC induces a heat-shock response in temperature-sensitive E.coli K165 by
CC elevating levels of sigma 32 (mechanism unknown).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA88527.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL591688; CAC46675.1; -; Genomic_DNA.
DR EMBL; M30934; AAA88527.1; ALT_FRAME; Genomic_DNA.
DR PIR; A44504; A44504.
DR RefSeq; NP_386202.1; NC_003047.1.
DR RefSeq; WP_010969699.1; NC_003047.1.
DR AlphaFoldDB; P15715; -.
DR STRING; 266834.SMc01492; -.
DR EnsemblBacteria; CAC46675; CAC46675; SMc01492.
DR GeneID; 61603561; -.
DR KEGG; sme:SMc01492; -.
DR PATRIC; fig|266834.11.peg.3553; -.
DR eggNOG; COG1752; Bacteria.
DR HOGENOM; CLU_026844_0_0_5; -.
DR OMA; ECDLVMK; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Cell membrane; Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..633
FT /note="RpoH suppressor"
FT /id="PRO_0000072304"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 11..410
FT /note="PNPLA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT REGION 342..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 41..45
FT /note="GXSXG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT MOTIF 397..399
FT /note="DGA/G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT ACT_SITE 43
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT ACT_SITE 397
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT CONFLICT 29
FT /note="A -> G (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 633 AA; 68699 MW; 87DCB54CF6D86804 CRC64;
MARTPAKYCD LVMKGGITSG IVYPNAALAL ARDYRFKNIG GTSAGAIAAA ACAAAAVGDR
RKQMKAAIAQ PEERVGFEGL AKASANLASP GFIKDLLQPA AGAGQAFRLL VTLAGNTGVL
RKGVALLGSV VRIAPVETLL LLAALAGLAY AVGGQTGMIA AALPAAICAY LGGVVFAVLR
IARVLRRNLM GLCTGTAPDQ PARRPRMVLT DWLHETLQAL SGKASGQPLT FGDLWTAERY
PGEPGSDRAV TLKMITTGIS HQEPRSLPFE SALFWFRRKE FEALFPKVVV DWMVEKAGEP
VTVAGEDYYL LPHGADMPVL VATRMSLSFP LLISAVPLHE PARRESLPGS DGENEAEDTT
SDEDEQKTVL DSTEALTTGG KKRRARPAAF RICWFSDGGI SSNFPIHLFD RALPRWPTFA
INLVYPETSD TGSRPEVFLP ENNRQGWQRH YQPIARKSAV HELCAFVFAI VATMQNWRDL
LQSRAPGHRE RIVHVSLSPQ EGGLNLAMSK EVLAAVSKKG TAAGEAFARF SFENHYWIRW
RNLASALQRY TIDIAASDAY RPKIPDYEPA YALAHDATSK PPSYRFASKA EREEAARLLE
KLIGEGEKWS GEGPDLTKTA PRPLPQLQIA PTY
