SUHW_DROAN
ID SUHW_DROAN Reviewed; 886 AA.
AC Q08875;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Protein suppressor of hairy wing;
GN Name=su(Hw);
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7916729; DOI=10.1101/gad.7.10.1966;
RA Harrison D.A., Gdula D.A., Coyne R.S., Corces V.G.;
RT "A leucine zipper domain of the suppressor of Hairy-wing protein mediates
RT its repressive effect on enhancer function.";
RL Genes Dev. 7:1966-1978(1993).
CC -!- FUNCTION: Su(Hw) controls the phenotypic effect of the gypsy
CC transposable element. Binds specifically to a region of the gipsy
CC element located 3' of the 5'LTR. It is probably a transcription factor.
CC Could play a role in the establishment of chromatin domains.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; Z25519; CAA80975.1; -; mRNA.
DR PIR; A48586; A48586.
DR AlphaFoldDB; Q08875; -.
DR SMR; Q08875; -.
DR STRING; 7217.FBpp0122042; -.
DR eggNOG; KOG1721; Eukaryota.
DR ChiTaRS; su(Hw); fly.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IEA:EnsemblMetazoa.
DR GO; GO:1990188; F:euchromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0033696; P:heterochromatin boundary formation; IEA:EnsemblMetazoa.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:EnsemblMetazoa.
DR GO; GO:1905632; P:protein localization to euchromatin; IEA:EnsemblMetazoa.
DR GO; GO:0035075; P:response to ecdysone; IEA:EnsemblMetazoa.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..886
FT /note="Protein suppressor of hairy wing"
FT /id="PRO_0000047052"
FT ZN_FING 221..243
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..314
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..367
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 498..520
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 524..546
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..578
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..623
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 24..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 100297 MW; C0CC79D5B8FA2836 CRC64;
MSAAKEGKEK KPVATVVKIV EVESVSPSKD KRPTRMKLLN NLSASSPQTY PPKTDKRSGI
KGSRIKILNE DVLVAPKVEK RRSTKPTSPG ATATSTVKIL NEKRIVPAEE TALETTKIKI
SPPKRNKMDH YVLQPVKVEN NKSASQATRG ATGEDEDTIA FILGDDDEVV PASTSRSNGQ
EILVTEEEEE EEEDDLDEEG DSPGGSNKNS GHKAIKEIVE HVCGKCYKTF RRLMSLKKHL
EFCRYDSGYH LRKAECWKNL EKIEKDGDVL EKKDICFCCC ESYDTFHLGH INCPDCPKSF
KTQTSYERHI FITHSEFSDY PCSICNANLR SEALLKLHEE QHKSRGKPYA CKICGKDFTR
SYHLKRHQKY SSCSANENDT MSCKVCDRVF YRLDNLRSHL KHHLGTQVVK KPEYMCHVCK
NCFYSLSTLN IHIRTHTGEK PFDCDLCDKK LSALVALKKH RRYHTGEKPY SCTVCNQAFA
VKEVLNRHMK RHTGERPHKC EECGKSFIQA TQLRTHSKTH IRPFACDMCE EKFKTEKQLE
RHVKEHSRQK RPYFSCTECK RHFRNTAQLK QHMDAGDHSE KSGEKPQRAK RSSTKVLERT
DCAICDKNFD SSETLRKHIR SVHECDPDDI FGIQPPSAKR AKINKIPKVD EEEEEEMVPV
ALNASSGSLI SSQTDDNGVV VREFLVDEGD GTAQTITLEN ETYTILPLDG EIAAEQITDE
GVKVEGQKTP PKKSPVVKKE KRKSLGASLA AAIADNIEVP PVEEDFEGEV LTEEDLKLKE
NIAKLIDMLA DPPILKKYGW PNAPEEMVLC KVIENCGYDL NKGAENYAEL DYGSRMREYC
KLLFTVVIHN DSIKSLLNNF PIDDVIEYVL GDEDQDEDGA DNGEGN
