ID   SUH_CIOIN               Reviewed;         554 AA.
AC   O76808;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Suppressor of hairless homolog;
DE            Short=Su(H);
GN   Name=Su(H);
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9808786; DOI=10.1006/dbio.1998.9067;
RA   Corbo J.C., Fujiwara S., Levine M., Di Gregorio A.;
RT   "Suppressor of hairless activates brachyury expression in the Ciona
RT   embryo.";
RL   Dev. Biol. 203:358-368(1998).
CC   -!- FUNCTION: Transcriptional regulator that plays a central role in Notch
CC       signaling, a signaling pathway involved in cell-cell communication that
CC       regulates a broad spectrum of cell-fate determinations. Acts as a
CC       transcriptional repressor when it is not associated with Notch
CC       proteins. When associated with some Notch protein, it acts as a
CC       transcriptional activator that activates transcription of Notch target
CC       genes (By similarity). Required for the transcriptional expression of
CC       Brachyury, suggesting that it participates in notochord
CC       differentiation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with activated Notch proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Su(H) family. {ECO:0000305}.
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DR   EMBL; AF085173; AAC34125.1; -; mRNA.
DR   RefSeq; NP_001027750.1; NM_001032578.1.
DR   AlphaFoldDB; O76808; -.
DR   SMR; O76808; -.
DR   STRING; 7719.NP_001027750.1; -.
DR   Ensembl; ENSCINT00000001527; ENSCINP00000001527; ENSCING00000000838.
DR   GeneID; 445779; -.
DR   KEGG; cin:445779; -.
DR   CTD; 34881; -.
DR   eggNOG; KOG3743; Eukaryota.
DR   GeneTree; ENSGT00390000005197; -.
DR   HOGENOM; CLU_022207_2_0_1; -.
DR   InParanoid; O76808; -.
DR   OMA; ISEVQWN; -.
DR   OrthoDB; 444988at2759; -.
DR   TreeFam; TF314117; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd01176; IPT_RBP-Jkappa; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.1450; -; 1.
DR   InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR   InterPro; IPR036358; BTD_sf.
DR   InterPro; IPR040159; CLS_fam.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR   InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR   InterPro; IPR038007; RBP-Jkappa_IPT.
DR   PANTHER; PTHR10665; PTHR10665; 1.
DR   Pfam; PF09270; BTD; 1.
DR   Pfam; PF09271; LAG1-DNAbind; 1.
DR   Pfam; PF20144; TIG_SUH; 1.
DR   SMART; SM01268; BTD; 1.
DR   SMART; SM01267; LAG1_DNAbind; 1.
DR   SUPFAM; SSF110217; SSF110217; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Notch signaling pathway;
KW   Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..554
FT                   /note="Suppressor of hairless homolog"
FT                   /id="PRO_0000208574"
FT   DOMAIN          381..471
FT                   /note="IPT/TIG"
FT   DNA_BIND        83..90
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        218..227
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        291..323
FT                   /evidence="ECO:0000250"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          489..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..523
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  61389 MW;  E7F93BBA2A3D6666 CRC64;
     MYHPHHLPAH GQVQSHQHRE DAAATSSRDV NGGLSVTESA IASFRSLREK YPPKKLTRDA
     MRRYLKDPND QTLIVLHAKV AQKSYGNEKR FFCPPPCMYL LGNGWKRKQQ ILEEEEGSSE
     AGQLHAFIGI GSSEQEMQQL HLDGKNFCTA KTLYISDTDK RKHFMLNVKM FFGGGGADVG
     QFSSKRIKVI SKPSKKKQSL KNADLCIASG TKVALFNRLR SQTVSTRYLH VEKGNFHASS
     IQWGCFAIHL LDDDESESEE FSVVDGYIHY GQTVKLVCSN TGMALPRLII RKVDKQTAIL
     DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP KETNKEMIND GASWTIISTD
     KAEYTFCDGM GPTADPVTPV PNVHSLQLNG GGDVAMLEVN GECFTSNLKV WFGEIEADTM
     FRCAEGLLCV VPDISAFREG WKWVKESVQV PINLVRNDGV IYPTNLTFTF TPEPGPRQHC
     PAALNILHGS KRPSASMPPT PVSGSEDDSG RGNESDRGDP IMPIKRPALD VHGRPVAPEA
     AATMNGANML RTAS