ID   SUH_DROSI               Reviewed;         102 AA.
AC   Q9Y1T5;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Protein suppressor of hairless;
DE   Flags: Fragment;
GN   Name=Su(H);
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10388820; DOI=10.1093/genetics/152.3.1017;
RA   Depaulis F., Brazier L., Veuille M.;
RT   "Selective sweep at the Drosophila melanogaster Suppressor of Hairless
RT   locus and its association with the In(2L)t inversion polymorphism.";
RL   Genetics 152:1017-1024(1999).
CC   -!- FUNCTION: Transcriptional regulator that plays a central role in Notch
CC       signaling, a signaling pathway involved in cell-cell communication that
CC       regulates a broad spectrum of cell-fate determinations. Binds directly
CC       the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the
CC       regulatory region of several genes. Required for neurogenesis in
CC       imaginal disks. Acts as a transcriptional repressor when it is not
CC       associated with Notch proteins. When associated with some Notch
CC       protein, it acts as a transcriptional activator that activates
CC       transcription of Notch target genes. Probably represses or activates
CC       transcription via the recruitment of chromatin remodeling complexes
CC       containing histone deacetylase or histone acetylase proteins,
CC       respectively. Specifically binds to the immunoglobulin kappa-type J
CC       segment recombination signal sequence. Required for transcription of
CC       Sim. Also functions independently of Notch pathway, in the development
CC       of the bristle sensory organ precursor cell (By similarity).
CC       {ECO:0000250|UniProtKB:P28159}.
CC   -!- SUBUNIT: Interacts with activated Notch. Interacts with Hairless, this
CC       interaction preventing its DNA-binding activity. Interacts with insv
CC       (via BEN domain) (By similarity). {ECO:0000250|UniProtKB:P28159}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28159}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P28159}. Note=In imaginal disk, at the onset of
CC       differentiation of socket cell, it is also present in the cytoplasm.
CC       {ECO:0000250|UniProtKB:P28159}.
CC   -!- SIMILARITY: Belongs to the Su(H) family. {ECO:0000305}.
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DR   EMBL; AF088275; AAD39718.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9Y1T5; -.
DR   SMR; Q9Y1T5; -.
DR   GO; GO:1990433; C:CSL-Notch-Mastermind transcription factor complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR   GO; GO:0090571; C:RNA polymerase II transcription repressor complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR   GO; GO:0035035; F:histone acetyltransferase binding; IEA:EnsemblMetazoa.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblMetazoa.
DR   GO; GO:0042688; P:crystal cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
DR   GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:EnsemblMetazoa.
DR   GO; GO:0016360; P:sensory organ precursor cell fate determination; ISS:UniProtKB.
DR   GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IEA:EnsemblMetazoa.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; Developmental protein; DNA-binding;
KW   Notch signaling pathway; Nucleus; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>102
FT                   /note="Protein suppressor of hairless"
FT                   /id="PRO_0000208573"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         102
SQ   SEQUENCE   102 AA;  12089 MW;  B4AB0DBE38C7E1F1 CRC64;
     NPNGSPLDPH QQQQQQQSQD MPHFGLPGPQ PPSSQQQQQQ MQVHHQQQQQ QQQQQQHQQQ
     MQMSLLPGPY RPHIEEKKLT RDAMEKYMRE RNDMVIVILH AK