ID   SUH_HALRO               Reviewed;         518 AA.
AC   O02019;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Suppressor of hairless homolog;
DE   AltName: Full=RBP-Jkappa;
GN   Name=RBP-JK;
OS   Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=7729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Shimokawa S., Kawaichi M.;
RT   "Structural and functional conservation of Halocynthia roretzi RBP-
RT   Jkappa.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator that plays a central role in Notch
CC       signaling, a signaling pathway involved in cell-cell communication that
CC       regulates a broad spectrum of cell-fate determinations. Acts as a
CC       transcriptional repressor when it is not associated with Notch
CC       proteins. When associated with some Notch protein, it acts as a
CC       transcriptional activator that activates transcription of Notch target
CC       genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with activated Notch proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Su(H) family. {ECO:0000305}.
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DR   EMBL; AB003695; BAA20141.1; -; mRNA.
DR   AlphaFoldDB; O02019; -.
DR   SMR; O02019; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd01176; IPT_RBP-Jkappa; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.1450; -; 1.
DR   InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR   InterPro; IPR036358; BTD_sf.
DR   InterPro; IPR040159; CLS_fam.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR   InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR   InterPro; IPR038007; RBP-Jkappa_IPT.
DR   PANTHER; PTHR10665; PTHR10665; 1.
DR   Pfam; PF09270; BTD; 1.
DR   Pfam; PF09271; LAG1-DNAbind; 1.
DR   Pfam; PF20144; TIG_SUH; 1.
DR   SMART; SM01268; BTD; 1.
DR   SMART; SM01267; LAG1_DNAbind; 1.
DR   SUPFAM; SSF110217; SSF110217; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Notch signaling pathway;
KW   Nucleus; Repeat; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..518
FT                   /note="Suppressor of hairless homolog"
FT                   /id="PRO_0000208575"
FT   DOMAIN          386..476
FT                   /note="IPT/TIG"
FT   DNA_BIND        89..96
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        223..232
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        296..328
FT                   /evidence="ECO:0000250"
FT   REGION          22..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  58370 MW;  5F0F10578521C1AD CRC64;
     MYHLNVTPDK QTSPHGCLVV SETDQQRSHV KERVNGTPNQ NGGTSTSSKP RSVFENRPPQ
     RLTREAMSKY LRERNDQTLI ILHAKVAQKS YGNEKRFLCP PPCLYLMESG WKQKQQILEE
     ADQAPEAGQV HAFIGIGSSD QEMQQLNLDG KNFCTAKTLY ISDTDKRKHF MLCVKMFFGS
     GLEVGAFNSR RIKVISKPSK KKQSLKNADL CIASGTKVAL FNRLRSQTVS TRYLHVENGN
     FHASSIQWGS FAIHLLDDDE SESEEFTVRD GYIHYGQTVK LVCSTTGMAL PRLIIRKVDK
     QTAILNADDP VSQLHKCAFY LKDSERMYLC LSQERIIQFQ ATPCPKEPNK EMINDGASWT
     IISTDKAEYT FCDGMGPTSK PVTPVPVVHS LQLNGGGDVA MLEVNGENFS PQLKVWFGEV
     EADTMYRCEE GLLCVVPDIS EFREGWTWVK QSVQVPINLV RHDGIIYPTN LTFTFTPEPG
     PRPTLARLLY ISSTPRDRIM PDRVPGRGVL IRPTWTTT